| Full text | |
| Author(s): |
Forgerini, Marcela
[1]
;
Lucchetta, Rosa Camila
[1]
;
Urbano, Gustavo
[2]
;
de Nadai, Tales Rubens
[3]
;
de Carvalho Mastroianni, Patricia
[1]
Total Authors: 5
|
| Affiliation: | [1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Drugs & Med, Araraquara, SP - Brazil
[2] Univ Sao Paulo, Sch Med, Dept Surg, Ribeirao Preto - Brazil
[3] Univ Sao Paulo, Bauru Sch Dent, Dept Publ Hlth, Bauru, SP - Brazil
Total Affiliations: 3
|
| Document type: | Review article |
| Source: | PHARMACOGENOMICS JOURNAL; v. 21, n. 1, p. 20-36, FEB 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Non-variceal upper gastrointestinal bleeding (non-variceal UGIB) is a frequent and severe adverse drug reaction. Idiosyncratic responses due to genetic susceptibility to non-variceal UGIB has been suggested. A systematic review was conducted to assess the association between genetic polymorphisms and non-variceal UGIB. Twenty-one publications and 7134 participants were included. Thirteen studies evaluated genetic polymorphism in patients exposed to non-steroidal anti-inflammatory drugs, low-dose aspirin, and warfarin. Eight studies present at least one methodological problem. Only six studies clearly defined that the outcome evaluated was non-variceal UGIB. Genetic polymorphisms involved in platelet activation and aggregation, angiogenesis, inflammatory process, and drug metabolism were associated with risk of non-variceal UGIB (NOS3, COX-1;COX-2;PLA2G7;GP1BA;GRS;IL1RN;F13A1;CDKN2B-AS1;DPP6;TBXA2R;TNF-alph a;VKORC1;CYP2C9;andAGT). Further well-designed studies are needed (e.g., clear restriction to non-variceal UGIB; proper selection of participants; and adjustment of confounding factors) to provide strong evidence for pharmacogenetic and personalized medicine. (AU) | |
| FAPESP's process: | 18/07501-9 - Genetic determinants of gastrointestinal bleeding associated with the use of ASA as an antiplalet agent: a case-control study |
| Grantee: | Marcela Forgerini |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 17/24193-3 - Genetic determinants of gastrointestinal bleeding associated with the use of ASA as an antiplalet agent: a case-control study |
| Grantee: | Patricia de Carvalho Mastroianni |
| Support Opportunities: | Regular Research Grants |