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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Genetic polymorphisms associated with upper gastrointestinal bleeding: a systematic review

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Author(s):
Forgerini, Marcela [1] ; Lucchetta, Rosa Camila [1] ; Urbano, Gustavo [2] ; de Nadai, Tales Rubens [3] ; de Carvalho Mastroianni, Patricia [1]
Total Authors: 5
Affiliation:
[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Drugs & Med, Araraquara, SP - Brazil
[2] Univ Sao Paulo, Sch Med, Dept Surg, Ribeirao Preto - Brazil
[3] Univ Sao Paulo, Bauru Sch Dent, Dept Publ Hlth, Bauru, SP - Brazil
Total Affiliations: 3
Document type: Review article
Source: PHARMACOGENOMICS JOURNAL; v. 21, n. 1, p. 20-36, FEB 2021.
Web of Science Citations: 0
Abstract

Non-variceal upper gastrointestinal bleeding (non-variceal UGIB) is a frequent and severe adverse drug reaction. Idiosyncratic responses due to genetic susceptibility to non-variceal UGIB has been suggested. A systematic review was conducted to assess the association between genetic polymorphisms and non-variceal UGIB. Twenty-one publications and 7134 participants were included. Thirteen studies evaluated genetic polymorphism in patients exposed to non-steroidal anti-inflammatory drugs, low-dose aspirin, and warfarin. Eight studies present at least one methodological problem. Only six studies clearly defined that the outcome evaluated was non-variceal UGIB. Genetic polymorphisms involved in platelet activation and aggregation, angiogenesis, inflammatory process, and drug metabolism were associated with risk of non-variceal UGIB (NOS3, COX-1;COX-2;PLA2G7;GP1BA;GRS;IL1RN;F13A1;CDKN2B-AS1;DPP6;TBXA2R;TNF-alph a;VKORC1;CYP2C9;andAGT). Further well-designed studies are needed (e.g., clear restriction to non-variceal UGIB; proper selection of participants; and adjustment of confounding factors) to provide strong evidence for pharmacogenetic and personalized medicine. (AU)

FAPESP's process: 18/07501-9 - Genetic determinants of gastrointestinal bleeding associated with the use of ASA as an antiplalet agent: a case-control study
Grantee:Marcela Forgerini
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 17/24193-3 - Genetic determinants of gastrointestinal bleeding associated with the use of ASA as an antiplalet agent: a case-control study
Grantee:Patricia de Carvalho Mastroianni
Support Opportunities: Regular Research Grants