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Genetic determinants of gastrointestinal bleeding associated with the use of ASA as an antiplalet agent: a case-control study

Grant number: 18/07501-9
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): October 01, 2018
Effective date (End): May 31, 2021
Field of knowledge:Health Sciences - Pharmacy
Principal researcher:Patricia de Carvalho Mastroianni
Grantee:Marcela Forgerini
Home Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

Gastrointestinal bleeding (HGI) is one of the most common adverse reactions with negative consequences. The different idiosyncratic responses observed related to HGI in individuals consuming Acetylsalicylic Acid (ASA) as an antiplatelet agent may be due to the presence of genetic variants in the genes encoding targets of pharmacokinetic and pharmacodynamic activity of AAS metabolism, such as cyclooxygenase 1 ( COX-1), the synthesis of endothelial nitric oxide (eNOS), cytochrome P450 (CYP2C9), P-glycoprotein transporter (ABCB1). Therefore, the objective of this study will be to determine the risk of HGI associated with ASA consumption and its relationship with genetic variants. Methods: A case-control study will be carried out. Cases (n = 300) will be considered as individuals with a diagnosis of ulcer perforation diagnosed by endoscopy. As a control, 900 subjects will be recruited who seek the preoperative unit for any painless surgical procedure. All subjects will be individually interviewed for aspirin use and other control and adjustment variables. Genomic DNA will be used to identify the SNP genotypes by real-time polymerase chain reaction (PCR) with the TaqPath ProAmp assay (Applied Biosystems®). A joint (pooled) analysis will be carried out with data from other research centers comprising hospitals in the region of Galicia, Spain, and Aveiro, Portugal. Mixed linear models will be used for dependent variables of the dichotomous type. (AU)

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Scientific publications (14)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FORGERINI, MARCELA; URBANO, GUSTAVO; NADAI, TALES RUBENS DE; BATAH, SABRINA SETEMBRE; FABRO, ALEXANDRE TODOROVIC; MASTROIANNI, PATRICIA DE CARVALHO. Genetic Variants in PTGS1 and NOS3 Genes Increase the Risk of Upper Gastrointestinal Bleeding: A Case-Control Study. FRONTIERS IN PHARMACOLOGY, v. 12, JUL 5 2021. Web of Science Citations: 0.
MARCELA FORGERINI; GUSTAVO URBANO; TALES RUBENS DE NADAI; MARUXA ZAPATA-CACHAFEIRO; RAFAEL KEMP; PATRÍCIA DE CARVALHO MASTROIANNI. EPIDEMIOLOGICAL PROFILE OF PATIENTS WITH NON-VARICEAL UPPER GASTROINTESTINAL BLEEDING SECONDARY TO PEPTIC DISEASE IN A TERTIARY REFERRAL BRAZILIAN HOSPITAL. Arq. Gastroenterol., v. 58, n. 2, p. 202-209, Jun. 2021.
FORGERINI, MARCELA; SCHIAVO, GEOVANA; LUCCHETTA, ROSA CAMILA; MASTROIANNI, PATRICIA DE CARVALHO. Drug interactions for elderly people with mental and behavioral disorders: a systematic scoping review. ARCHIVES OF GERONTOLOGY AND GERIATRICS, v. 93, MAR-APR 2021. Web of Science Citations: 0.
FORGERINI, MARCELA; LUCCHETTA, ROSA CAMILA; URBANO, GUSTAVO; DE NADAI, TALES RUBENS; DE CARVALHO MASTROIANNI, PATRICIA. Genetic polymorphisms associated with upper gastrointestinal bleeding: a systematic review. PHARMACOGENOMICS JOURNAL, v. 21, n. 1, p. 20-36, FEB 2021. Web of Science Citations: 0.
ROSA CAMILA LUCCHETTA; SOPHIA DE ANDRADE CAVICCHIOLI; ANA LUÍSA RODRIGUEZ GINI; MARCELA FORGERINI; FABIANA ROSSI VARALLO; MARIANE NUNES DE NADAI; FERNANDO FERNANDEZ-LLIMOS; PATRICIA DE CARVALHO MASTROIANNI. Deficiency of vitamins C and E in women of childbearing age in Brazil: a systematic review and meta-analysis. São Paulo Medical Journal, n. ahead, p. -, 2021.
ROSA CAMILA LUCCHETTA; SOPHIA DE ANDRADE CAVICCHIOLI; ANA LUÍSA RODRIGUEZ GINI; MARCELA FORGERINI; FABIANA ROSSI VARALLO; MARIANE NUNES DE NADAI; FERNANDO FERNANDEZ-LLIMOS; PATRICIA DE CARVALHO MASTROIANNI. Deficiency of vitamins C and E in women of childbearing age in Brazil: a systematic review and meta-analysis. São Paulo Medical Journal, v. 139, n. 6, p. 545-555, Dez. 2021.
MARCELA FORGERINI; MARIA TERESA HERDEIRO; JOSÉ CARLOS FERNANDES GALDURÓZ; PATRÍCIA DE CARVALHO MASTROIANNI. Risk factors associated with drug therapy among elderly people with Alzheimer’s disease: a cross-sectional study. São Paulo Medical Journal, v. 138, n. 3, p. 216-218, Jun. 2020.
FORGERINI, MARCELA; HERDEIRO, MARIA TERESA; FERNANDES GALDUROZ, JOSE CARLOS; MASTROIANNI, PATRICIA DE CARVALHO. Risk factors associated with drug therapy among elderly people with Alzheimer's disease: a cross-sectional study. São Paulo Medical Journal, v. 138, n. 3, p. 216-228, MAY-JUN 2020. Web of Science Citations: 0.
MARCELA FORGERINI; PATRÍCIA DE CARVALHO MASTROIANNI. Monitoring compliance with Clinical Protocol and Therapeutic Guidelines for Alzheimer’s disease. Dement. Neuropsychol., v. 14, n. 1, p. 24-27, Mar. 2020.
MARCELA FORGERINI; MARIA TERESA HERDEIRO; JOSÉ CARLOS FERNANDES GALDURÓZ; PATRÍCIA DE CARVALHO MASTROIANNI. Risk factors associated with drug therapy among elderly people with Alzheimer’s disease: a cross-sectional study. São Paulo Medical Journal, n. ahead, p. -, 2020.
FABIANA ROSSI VARALLO; ROSA CAMILA LUCCHETTA; MARCELA FORGERINI; PATRICIA DE CARVALHO MASTROIANNI. What would be a trigger tool with better performance for detecting drug-induced hyperkalemia?. São Paulo Medical Journal, v. 137, n. 4, p. 386-387, Jul. 2019. Web of Science Citations: 1.
VARALLO, FABIANA ROSSI; FORGERINI, MARCELA; HERDEIRO, MARIA TERESA; MASTROIANNI, PATRICIA DE CARVALHO. Harmonization of Pharmacovigilance Regulation in Brazil: Opportunities to Improve Risk Communication. CLINICAL THERAPEUTICS, v. 41, n. 3, p. 598-603, MAR 2019. Web of Science Citations: 0.
FABIANA ROSSI VARALLO; ROSA CAMILA LUCCHETTA; MARCELA FORGERINI; PATRICIA DE CARVALHO MASTROIANNI. What would be a trigger tool with better performance for detecting drug-induced hyperkalemia?. São Paulo Medical Journal, n. ahead, p. -, 2019.
FORGERINI, MARCELA; VARALLO, FABIANA ROSSI; ALVES DE OLIVEIRA, ALICE ROSA; DE NADA, TALES RUBENS; MASTROIANNI, PATRICIA DE CARVALHO. Assessment of the adherence to and costs of the prophylaxis protocol for venous thromboembolism. Clinics, v. 74, 2019. Web of Science Citations: 0.

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