Genetic determinants of gastrointestinal bleeding associated with the use of ASA as an antiplalet agent: a case-control study

• Grant number: 18/07501-9
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: October 01, 2018
• End date: May 31, 2021
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Patricia de Carvalho Mastroianni
• Grantee: Marcela Forgerini
• Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

Gastrointestinal bleeding (HGI) is one of the most common adverse reactions with negative consequences. The different idiosyncratic responses observed related to HGI in individuals consuming Acetylsalicylic Acid (ASA) as an antiplatelet agent may be due to the presence of genetic variants in the genes encoding targets of pharmacokinetic and pharmacodynamic activity of AAS metabolism, such as cyclooxygenase 1 ( COX-1), the synthesis of endothelial nitric oxide (eNOS), cytochrome P450 (CYP2C9), P-glycoprotein transporter (ABCB1). Therefore, the objective of this study will be to determine the risk of HGI associated with ASA consumption and its relationship with genetic variants. Methods: A case-control study will be carried out. Cases (n = 300) will be considered as individuals with a diagnosis of ulcer perforation diagnosed by endoscopy. As a control, 900 subjects will be recruited who seek the preoperative unit for any painless surgical procedure. All subjects will be individually interviewed for aspirin use and other control and adjustment variables. Genomic DNA will be used to identify the SNP genotypes by real-time polymerase chain reaction (PCR) with the TaqPath ProAmp assay (Applied Biosystems®). A joint (pooled) analysis will be carried out with data from other research centers comprising hospitals in the region of Galicia, Spain, and Aveiro, Portugal. Mixed linear models will be used for dependent variables of the dichotomous type. (AU)

Scientific publications

(22)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MASTROIANNI, PATRICIA DE CARVALHO; FORGERINI, MARCELA. Compliance and drug-related problems in probable Alzheimer's disease elderly. INTERNATIONAL PSYCHOGERIATRICS, v. 31, n. 11, SI, p. 1677-1678, NOV 2019. (14/00312-5, 18/07501-9)

MARCELA FORGERINI; MARIA TERESA HERDEIRO; JOSÉ CARLOS FERNANDES GALDURÓZ; PATRÍCIA DE CARVALHO MASTROIANNI. Risk factors associated with drug therapy among elderly people with Alzheimer’s disease: a cross-sectional study. São Paulo Medical Journal, v. 138, n. 3, p. 216-218, 2020-06-22. (18/07501-9, 13/12681-2)

FORGERINI, MARCELA; URBANO, GUSTAVO; NADAI, TALES RUBENS DE; BATAH, SABRINA SETEMBRE; FABRO, ALEXANDRE TODOROVIC; MASTROIANNI, PATRICIA DE CARVALHO. Genetic Variants in PTGS1 and NOS3 Genes Increase the Risk of Upper Gastrointestinal Bleeding: A Case-Control Study. FRONTIERS IN PHARMACOLOGY, v. 12, JUL 5 2021. (19/19591-5, 17/24193-3, 18/07501-9)

FORGERINI, MARCELA; VARALLO, FABIANA ROSSI; ALVES DE OLIVEIRA, ALICE ROSA; DE NADA, TALES RUBENS; MASTROIANNI, PATRICIA DE CARVALHO. Assessment of the adherence to and costs of the prophylaxis protocol for venous thromboembolism. Clinics, v. 74, 2019. (18/07501-9, 13/12681-2)

VARALLO, FABIANA ROSSI; FORGERINI, MARCELA; HERDEIRO, MARIA TERESA; MASTROIANNI, PATRICIA DE CARVALHO. Harmonization of Pharmacovigilance Regulation in Brazil: Opportunities to Improve Risk Communication. CLINICAL THERAPEUTICS, v. 41, n. 3, p. 598-603, MAR 2019. (18/07501-9, 13/12681-2)

ROSA CAMILA LUCCHETTA; SOPHIA DE ANDRADE CAVICCHIOLI; ANA LUÍSA RODRIGUEZ GINI; MARCELA FORGERINI; FABIANA ROSSI VARALLO; MARIANE NUNES DE NADAI; FERNANDO FERNANDEZ-LLIMOS; PATRICIA DE CARVALHO MASTROIANNI. Deficiency of vitamins C and E in women of childbearing age in Brazil: a systematic review and meta-analysis. São Paulo Medical Journal, v. 139, n. 6, p. 545-555, 2021-09-27. (18/07501-9)

MARCELA FORGERINI; GUSTAVO URBANO; TALES RUBENS DE NADAI; MARUXA ZAPATA-CACHAFEIRO; RAFAEL KEMP; PATRÍCIA DE CARVALHO MASTROIANNI. Perfil epidemiológico de pacientes com hemorragia gastrointestinal alta não varicosa decorrente de doença péptica em um hospital brasileiro terciário de referência. Arq. Gastroenterol., v. 58, n. 2, p. 202-209, 2021-06-25. (17/24193-3, 18/07501-9)

ROSA CAMILA LUCCHETTA; SOPHIA DE ANDRADE CAVICCHIOLI; ANA LUÍSA RODRIGUEZ GINI; MARCELA FORGERINI; FABIANA ROSSI VARALLO; MARIANE NUNES DE NADAI; FERNANDO FERNANDEZ-LLIMOS; PATRICIA DE CARVALHO MASTROIANNI. Deficiency of vitamins C and E in women of childbearing age in Brazil: a systematic review and meta-analysis. São Paulo Medical Journal, n. ahead, p. -, 2021. (18/07501-9)

FORGERINI, MARCELA; HERDEIRO, MARIA TERESA; FERNANDES GALDUROZ, JOSE CARLOS; MASTROIANNI, PATRICIA DE CARVALHO. Risk factors associated with drug therapy among elderly people with Alzheimer's disease: a cross-sectional study. São Paulo Medical Journal, v. 138, n. 3, p. 216-228, MAY-JUN 2020. (18/07501-9, 13/12681-2)

MARCELA FORGERINI; PATRÍCIA DE CARVALHO MASTROIANNI. MONITORAMENTO DO CUMPRIMENTO DO PROTOCOLO CLÍNICO E DIRETRIZES TERAPÊUTICAS DA DOENÇA DE ALZHEIMER. Dement. Neuropsychol., v. 14, n. 1, p. 24-27, 2020-03-16. (18/07501-9)

FABIANA ROSSI VARALLO; ROSA CAMILA LUCCHETTA; MARCELA FORGERINI; PATRICIA DE CARVALHO MASTROIANNI. What would be a trigger tool with better performance for detecting drug-induced hyperkalemia?. São Paulo Medical Journal, v. 137, n. 4, p. 386-387, Jul. 2019. (18/07501-9, 13/12681-2)

FORGERINI, MARCELA; LUCCHETTA, ROSA CAMILA; URBANO, GUSTAVO; DE NADAI, TALES RUBENS; DE CARVALHO MASTROIANNI, PATRICIA. Genetic polymorphisms associated with upper gastrointestinal bleeding: a systematic review. PHARMACOGENOMICS JOURNAL, v. 21, n. 1, p. 20-36, FEB 2021. (18/07501-9, 17/24193-3)

SCHIAVO, GEOVANA; FORGERINI, MARCELA; LUCCHETTA, ROSA CAMILA; MASTROIANNI, PATRICIA DE CARVALHO. A comprehensive look at explicit screening tools for potentially inappropriate medication: A systematic scoping review. AUSTRALASIAN JOURNAL ON AGEING, v. N/A, p. 26-pg., 2022-02-28. (18/07501-9, 19/01565-8)

FORGERINI, MARCELA; URBANO, GUSTAVO; DE NADAI, TALES RUBENS; ZANELLI, CLESLEI FERNANDO; VALENTINI, SANDRO ROBERTO; MASTROIANNI, PATRICIA DE CARVALHO. VNTR Polymorphism in Intron 4 of the eNOS Gene and the Risk of Gastrointestinal Bleeding: A Case-control Study. JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES, v. 31, n. 2, p. 8-pg., 2022-04-06. (18/07501-9, 17/24193-3)

MARCELA FORGERINI; ROSA CAMILA LUCCHETTA; FERNANDA MARIANA OLIVEIRA; MARIA TERESA HERDEIRO; MARISA VEIGA CAPELA; PATRÍCIA DE CARVALHO MASTROIANNI. Impact of pharmacist intervention in patients with Alzheimer's disease. Brazilian Journal of Pharmaceutical Sciences, v. 58, 2022-08-08. (18/07501-9, 14/00312-5)

ROSA CAMILA LUCCHETTA; ISABELE HELD LEMOS; ANA LUÍSA RODRIGUEZ GINI; SOPHIA DE ANDRADE CAVICCHIOLI; MARCELA FORGERINI; FABIANA ROSSI VARALLO; MARIANE NUNES DE NADAI; FERNANDO FERNANDEZ-LLIMOS; PATRICIA DE CARVALHO MASTROIANNI. Deficiência e insuficiência de vitamina D em mulheres na idade reprodutiva: Uma revisão sistemática e meta-análise. Revista Brasileira de Ginecologia e Obstetrícia, v. 44, n. 4, p. 409-424, 2022-06-27. (18/07501-9)

RC LUCCHETTA; MN DE-NADAI; G SCHIAVO; GM DE-SOUZA; M FORGERINI; PC MASTROIANNI. Estratégias para melhorar conhecimentos, atitudes e práticas quanto às medidas de controle e prevenção da COVID-19: uma revisão sistemática. Revista de la OFIL, v. 32, n. 1, p. 89-97, 2022-11-21. (19/01565-8, 18/07501-9)

LUCCHETTA, ROSA CAMILA; LEMOS, ISABELE HELD; GINI, ANA LUISA RODRIGUEZ; CAVICCHIOLI, SOPHIA DE ANDRADE; FORGERINI, MARCELA; VARALLO, FABIANA ROSSI; DE NADAI, MARIANE NUNES; FERNANDEZ-LLIMOS, FERNANDO; MASTROIANNI, PATRICIA DE CARVALHO. Deficiency and Insufficiency of Vitamin D in Women of Childbearing Age: A Systematic Review and Meta-analysis. Revista Brasileira de Ginecologia e Obstetrícia, v. 44, n. 04, p. 16-pg., 2022-02-24. (18/07501-9)

FORGERINI, MARCELA; SCHIAVO, GEOVANA; LUCCHETTA, ROSA CAMILA; MASTROIANNI, PATRICIA DE CARVALHO. Drug interactions for elderly people with mental and behavioral disorders: a systematic scoping review. ARCHIVES OF GERONTOLOGY AND GERIATRICS, v. 93, MAR-APR 2021. (18/07501-9)

FORGERINI, MARCELA; URBANO, GUSTAVO; DE NADAI, TALES RUBENS; BATAH, SABRINA SETEMBRE; FABRO, ALEXANDRE TODOROVIC; MASTROIANNI, PATRICIA DE CARVALHO. The role of CYP2C9*2, CYP2C9*3 and VKORC1-1639 variants on the susceptibility of upper gastrointestinal bleeding: A full case-control study. JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, v. 26, p. 13-pg., 2023-01-30. (18/07501-9, 17/24193-3)

FORGERINI, MARCELA; SCHIAVO, GEOVANA; URBANO, GUSTAVO; DE NADAI, TALES RUBENS; ZAPATA-CACHAFEIRO, MARUXA; HERDEIRO, MARIA TERESA; DE CARVALHO MASTROIANNI, PATRICIA. Use of Antidepressants and the Risk of Upper Gastrointestinal Tract Bleeding: A Case-control Study. CLINICAL THERAPEUTICS, v. 45, n. 7, p. 8-pg., 2023-07-01. (18/07501-9)

MASTROIANNI, PATRICIA DE CARVALHO; FORGERINI, MARCELA. Compliance and drug-related problems in probable Alzheimer's disease elderly. INTERNATIONAL PSYCHOGERIATRICS, v. 31, n. 11, p. 2-pg., 2019-11-01. (18/07501-9, 14/00312-5)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

FORGERINI, Marcela. Genetic variants and factors associated with the risk of upper gastrointestinal bleeding: a case-control study. 2021. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Farmacêuticas. Araraquara Araraquara.