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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Macular and choroidal thickness after intracameral moxifloxacin for prevention of postcataract endophthalmitis

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Autor(es):
Ferreira, Bruna Gil [1] ; Cardoso da Silva, Iuri [1] ; Melega, Mathias Violante [1] ; Nascimento, Mauricio Abujamra [1] ; Cavalcanti Lira, Rodrigo Pessoa [1] ; Leite Arieta, Carlos Eduardo [1] ; Alves, Monica [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Campinas UNICAMP, Dept Ophthalmol & Otorhinolaryngol, Sch Med Sci, Rua Tessalia Vieira de Camargo, Cidade Univ, BR-13083887 Sao Paulo - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF CATARACT AND REFRACTIVE SURGERY; v. 47, n. 1, p. 40-45, JAN 2021.
Citações Web of Science: 0
Resumo

Purpose: To determine any changes in macular or choroidal thickness associated with the use of intracameral moxifloxacin as postcataract endophthalmitis prophylaxis. Setting: University of Campinas, Campinas, Sao Paulo, Brazil. Design: Prospective, randomized, partially masked, single-site clinical trial. Methods: Phacoemulsification surgery patients in the experimental group (Group A) received a 0.03 mL intracameral injection of undiluted moxifloxacin from a sealed bottle immediately after phacoemulsification surgery (150 mu g in 0.03 mL-Vigamox solution), whereas the control group (Group B) did not. Investigators evaluated in masked fashion macular and choroidal thickness using spectral-domain optical coherance tomography preoperatively and postoperatively. Results: A total of 93 patients were included (48 in Group A and 45 in Group B). Baseline parameters were similar between the groups. Either of the 2 parameters assessed differed statistically between the groups or preoperatively vs postoperatively. On postoperative day 30, central macular thickness was 8.85 +/- 14.78 mu m in Group A and 10.26 +/- 22.44 mu m in Group B (P = .7232); choroidal thickness as measured by enhanced depth imaging (EDI) was 1.45 +/- 16.13 mu m in Group A and 3.74 +/- 16.15 in Group B (P = .5017). On postoperative day 60, central macular thickness was 19.53 +/- 39.28 mu m in Group A and 17.14 +/- 53.68 mu m in Group B (P = .8363); EDI was 5.08 +/- 21.96 mu m in Group A and 5.24 +/- 15.8 in Group B (P = .9752). Conclusions: The application of intracameral injection of 0.03 mL of undiluted 0.5% moxifloxacin during phacoemulsification surgery as endophthalmitis prophylaxis induced no changes in macular or choroidal thickness. Copyright (C) 2020 Published by Wolters Kluwer on behalf of ASCRS and ESCRS (AU)

Processo FAPESP: 14/19138-5 - Criação do biobanco de tecidos oculares e investigação de novos mecanismos fisiopatológicos relacionados a doenças oculares do segmento anterior
Beneficiário:Mônica de Cássia Alves
Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores