Curcuma longaL. helps macrophages to control opportunistic micro-organisms during host-microbe interactions

Autor(es)

Figueira, Leandro W. ^[1] ; de Oliveira, Jonatas R. ^{[1, 2]} ; Netto, Amandio A. L. ^[3] ; Zamarioli, Lucas dos S. ^[4] ; Marcucci, Maria C. ^[3] ; Camargose, Samira E. A. ^[5] ; de Oliveira, Luciane D. ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Inst Sci & Technol, Dept Biosci & Oral Diag, Av Engenheiro Francisco Jose Longo 777, BR-2245000 Sao Jose Dos Campos, SP - Brazil

^[2] Anhembi Morumbi Univ, Sch Med, Av Dep Benedito Matarazzo 4050, BR-12230002 Sao Jose Dos Campos, SP - Brazil

^[3] Anhanguera Univ, Av Raimundo Pereira Magalhaes 3305, BR-05145200 Sao Paulo, SP - Brazil

^[4] Fed Univ Sao Paulo UNIFESP, Inst Pharmacol & Mol Biol, Dept Mode Drug Act, Rua Tres de Maio 100, BR-04044020 Sao Paulo, SP - Brazil

^[5] Univ Florida, Coll Dent, Dept Restorat Dent Sci, 1395 Ctr Dr, Gainesville, FL 32610 - USA

• Tipo de documento: Artigo Científico
• Fonte: FUTURE MICROBIOLOGY; v. 15, n. 13, p. 1237-1248, SEP 2020.
• Citações Web of Science: 0

Resumo

Aim:Plant products have been evaluated to control opportunistic micro-organisms, as well as fortify immune system cells. Thus,Curcuma longaL. (turmeric) extract was evaluated in interactions of murine macrophages (RAW 264.7) withStaphylococcus aureus,Pseudomonas aeruginosa andCandida albicans, in order to establish cooperation with defense cells.Materials \& methods:Effects of minimal inhibitory concentrations (MIC) of the plant extract were analyzed on phagocytosis, cell viability of RAW 264.7 and production of inflammation-related molecules (IL-1 beta, TNF-alpha, IL-10 and NO).Results:The plant extract was cytocompatible and promoted significant reductions of micro-organisms, and synthesis of inflammation-related molecules, during interactions.Conclusion:C. longaL. extract showed significant antimicrobial response and cooperation with macrophages, by fighting bacteria and yeasts during host-microbe interactions. (AU)

• Processo FAPESP: 15/08776-3 - Atividade antimicrobiana, anti-inflamatória, citotoxicidade e genotoxicidade de diferentes extratos naturais
• Beneficiário: Luciane Dias de Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular