Center of pressure responses to unpredictable external perturbations indicate low accuracy in predicting fall risk in people with Parkinson's disease

Autor(es)

Moraca, Gabriel Antonio Gazziero ^[1] ; Beretta, Victor Spiandor ^{[2, 1]} ; dos Santos, Paulo Cezar Rocha ^{[3, 2, 1]} ; Nobrega-Sousa, Priscila ^{[2, 1]} ; Orcioli-Silva, Diego ^{[2, 1]} ; Vitorio, Rodrigo ^{[4, 2, 1]} ; Gobbi, Lilian Teresa Bucken ^{[2, 1]}

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ Unesp, Inst Biosci Posture & Gait Studies Lab LEPLO, Ave 24-A, 1515 Bela Vista, BR-13500690 Rio Claro, SP - Brazil

^[2] Sao Paulo State Univ UNESP, Grad Program Movement Sci, Rio Claro - Brazil

^[3] Univ Groningen, Univ Med Ctr Groningen, Ctr Human Movement Sci, Groningen - Netherlands

^[4] Oregon Hlth & Sci Univ, Dept Neurol, Portland, OR 97201 - USA

• Tipo de documento: Artigo Científico
• Fonte: European Journal of Neuroscience; v. 53, n. 8 FEB 2021.
• Citações Web of Science: 0

Resumo

Falls are associated with impairment in postural control in people with Parkinson's disease (PwPD). We aimed to predict the fall risk through models combining postural responses with clinical and cognitive measures. Also, we compared the center of pressure (CoP) between PwPD fallers and non-fallers after unpredictable external perturbations. We expected that CoP parameters combined with clinical and cognitive measures would predict fall risk. Seventy-five individuals participated in the study. CoP parameters were measured during postural responses through five trials with unpredictable translations of the support-surface in posterior direction. Range and peak of CoP were analyzed in two periods: early and late responses. Time to peak (negative peak) and recovery time were analyzed regardless of the periods. Models included the CoP parameters in early (model 1), late responses (model 2), and temporal parameters (model 3). Clinical and cognitive measures were entered into all models. Twenty-nine participants fell at least once, and 46 PwPD did not fall during 12 months following the postural assessment. Range of CoP in late responses was associated with fall risk (p = .046). However, although statistically non-significant, this parameter indicated low accuracy in predicting fall risk (area under the curve = 0.58). Fallers presented a higher range of CoP in early responses than non-fallers (p = .033). In conclusion, although an association was observed between fall risk and range of CoP in late responses, this parameter indicated low accuracy in predicting fall risk in PwPD. Also, fallers demonstrate worse postural control during early responses after external perturbations than non-fallers, measured by CoP parameters. (AU)

• Processo FAPESP: 16/00503-0 - Ajustes posturais sob perturbação externa em indivíduos com Doença de Parkinson e neurologicamente sadios
• Beneficiário: Victor Spiandor Beretta
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 19/01203-9 - Respostas posturais reativas predizem quedas em pacientes com Doença de Parkinson?
• Beneficiário: Gabriel Antonio Gazziero Moraca
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica