3,4-Methylenedioxypyrovalerone (MDPV) Sensing Based on Electropolymerized Molecularly Imprinted Polymers on Silver Nanoparticles and Carboxylated Multi-Walled Carbon Nanotubes

Autor(es):Mostrar menos -

Couto, Rosa A. S. ^[1] ; Coelho, Constantino ^[1] ; Mounssef, Jr., Bassim ^[2] ; Morais, Sara F. de A. ^[2] ; Lima, Camila D. ^[3] ; dos Santos, Wallans T. P. ^[4] ; Carvalho, Felix ^[5] ; Rodrigues, Cecilia M. P. ^[6] ; Braga, Ataualpa A. C. ^[2] ; Goncalves, Luis Moreira ^[2] ; Beatriz Quinaz, M. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Porto, Fac Pharm, Dept Chem Sci, REQUIMTE, LAQV, Lab Appl Chem, P-4050213 Porto - Portugal

^[2] Univ Sao Paulo, Dept Quim Fundamental, Inst Quim, BR-05508000 Sao Paulo, SP - Brazil

^[3] Univ Fed Vales Jequitinhonha & Mucuri, Dept Quim, BR-39100000 Diamantina, MG - Brazil

^[4] Univ Fed Vales Jequitinhonha & Mucuri, Dept Farm, BR-39100000 Diamantina, MG - Brazil

^[5] Univ Porto, Fac Pharm, Dept Biol Sci, REQUIMTE, UCIBIO, Lab Toxicol, P-4050213 Porto - Portugal

^[6] Univ Lisbon, Fac Pharm, Res Inst Med iMed ULisboa, P-1649003 Lisbon - Portugal

• Tipo de documento: Artigo Científico
• Fonte: NANOMATERIALS; v. 11, n. 2 FEB 2021.
• Citações Web of Science: 0

Resumo

3,4-methylenedioxypyrovalerone (MDPV) is a harmful and controlled synthetic cathinone used as a psychostimulant drug and as sport-enhancing substance. A sensor was developed for the direct analysis of MDPV by transducing its oxidation signal by means of an electropolymerized molecularly imprinted polymer (e-MIP) built in-situ on the screen-printed carbon electrode's (SPCE) surface previously covered with multi-walled carbon nanotubes (MWCNTs) and silver nanoparticles (AgNPs). Benzene-1,2-diamine was used as the functional monomer while the analyte was used as the template monomer. Each step of the sensor's development was studied by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) in a solution containing ferricyanide, however no redox probe was required for the actual MDPV measurements. The interaction between the poly(o-phenylenediamine) imprinted polymer and MDPV was studied by density-functional theory (DFT) methods. The SPCE-MWCNT-AgNP-MIP sensor responded adequately to the variation of MDPV concentration. It was shown that AgNPs enhanced the electrochemical signal by around a 3-fold factor. Making use of square-wave voltammetry (SWV) the developed sensor provided a limit of detection (LOD) of 1.8 mu mol L-1. The analytical performance of the proposed sensor paves the way to the development of a portable device for MDPV on-site sensing to be applied in forensic and doping analysis. (AU)

• Processo FAPESP: 18/14425-7 - Um novo rumo sinérgico para a microextração por difusão gasosa (GDME) fazendo uso de polímeros com impressão molecular (MIPs)
• Beneficiário: Luís Francisco Moreira Gonçalves
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 15/01491-3 - Estudo teórico das reações de acoplamento-cruzado: catálise homogênea e heterogênea
• Beneficiário: Ataualpa Albert Carmo Braga
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/25770-6 - Novas fronteiras em reações de acoplamento cruzado mediadas por paládio: associando catálise enantiosseletiva, ativações C-H, novos materiais e reações em fluxo visando alta eficiência e sustentabilidade em processos sintéticos
• Beneficiário: Carlos Roque Duarte Correia
• Modalidade de apoio: Auxílio à Pesquisa - Temático