Effects of FTO and PPARγ variants on intrauterine growth restriction in a Brazilian birth cohort

Autor(es)

M.R. Barbieri ^[1] ; A.M. Fontes ^[2] ; M.A. Barbieri ^[3] ; M.C.P. Saraiva ^[4] ; V.M.F. Simões ^[5] ; A.A.M. da Silva ^[6] ; K.J. Abraham ^[7] ; H. Bettiol ^[8]

Afiliação do(s) autor(es)

^[1] Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Puericultura e Pediatria - Brasil

^[2] Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Genética - Brasil

^[3] Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Puericultura e Pediatria - Brasil

^[4] Universidade de São Paulo. Faculdade de Odontologia de Ribeirão Preto. Departamento de Clínica Infantil - Brasil

^[5] Universidade Federal do Maranhão. Centro de Ciências da Saúde. Departamento de Saúde Pública - Brasil

^[6] Universidade Federal do Maranhão. Centro de Ciências da Saúde. Departamento de Saúde Pública - Brasil

^[7] Universidade de São Paulo. Faculdade de Economia, Administração e Contabilidade de Ribeirão Preto. Departamento de Economia - Brasil

^[8] Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Puericultura e Pediatria - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Medical and Biological Research; v. 54, n. 1 2021-03-10.

Resumo

Intrauterine growth restriction (IUGR) is related to a higher risk of neonatal mortality, minor cognitive deficit, metabolic syndrome, and cardiovascular disease in adulthood. In previous studies, genetic variants in the FTO (fat mass and obesity-associated) and PPARγ (peroxisome proliferator-activated receptor-gamma) genes have been associated with metabolic disease, body mass index, and obesity among other outcomes. We studied the association of selected FTO (rs1421085, rs55682395, rs17817449, rs8043757, rs9926289, and rs9939609) and PPARγ (rs10865710, rs17036263, rs35206526, rs1801282, rs28763894, rs41516544, rs62243567, rs3856806, and rs1805151) single-nucleotide polymorphisms (SNPs) with IUGR, through a case-control study in a cohort of live births that occurred from June 1978 to May 1979 in a Brazilian city. We selected 280 IUGR cases and 256 controls for analysis. Logistic regression was used to jointly analyze the SNPs as well as factors such as maternal smoking, age, and schooling. We found that the PPARγ rs41516544 increased the risk of IUGR for male offspring (OR 27.83, 95%CI 3.65-212.32) as well as for female offspring (OR=8.94, 95%CI: 1.96-40.88). The FTO rs9939609 TA genotype resulted in a reduced susceptibility to IUGR for male offspring only (OR=0.47, 95%CI: 0.26-0.86). In conclusion, we demonstrated that PPARγ SNP had a positive effect and FTO SNP had a negative effect on IUGR occurrence, and these effects were gender-specific. (AU)

• Processo FAPESP: 00/09508-7 - Da saúde perinatal à saúde do adulto jovem: estudo da coorte nascida em 1978/79 nos hospitais de Ribeirão Preto, SP
• Beneficiário: Marco Antonio Barbieri
• Modalidade de apoio: Auxílio à Pesquisa - Temático