Pulmonary adiaspiromycosis in armadillos killed by motor vehicle collisions in Brazil

Autor(es)

Navas-Suarez, Pedro Enrique ^[1] ; Sacristan, Carlos ^[1] ; Diaz-Delgado, Josue ^{[2, 1]} ; Yogui, Debora R. ^{[3, 4]} ; Alves, Mario Henrique ^{[3, 5]} ; Fuentes-Castillo, Danny ^[1] ; Ospina-Pinto, Catalina ^[1] ; Zamana, Roberta Ramblas ^[1] ; Jean Desbiez, Arnaud Leonard ^{[3, 6]} ; Catao-Dias, Jose Luiz ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Vet Med & Anim Sci FMVZ, Dept Pathol VPT, Sao Paulo - Brazil

^[2] Texas A&M Vet Med Diagnost Lab, College Stn, TX - USA

^[3] Inst Conservacao Anim Silvestres ICAS, Campo Grande, MS - Brazil

^[4] Nashville Zoo, Nashville, TN - USA

^[5] Houston Zoo, Houston, TX - USA

^[6] Royal Zool Soc Scotland, Edinburgh, Midlothian - Scotland

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 11, n. 1 JAN 11 2021.
• Citações Web of Science: 1

Resumo

Knowledge of infectious diseases in wildlife provides important information for preventing potential outbreaks of zoonotic diseases. Adiaspiromycosis is a neglected human disease caused by dimorphic Onygenales fungi. The disease is produced by the inflammatory response against growing adiaspores, leading to granulomatous pneumonia. In humans, adiaspiromycosis is relevant in immunosuppressed patients. In animals, it is associated with pneumonia in fossorial species. Given the potential role of armadillos in the epidemiology of adiaspiromycosis, in this study, we sought to investigate the occurrence and pathological features of adiaspiromycosis in roadkilled armadillos. In total, 54 armadillo carcasses were suitable for postmortem pathologic examinations between February 2017 and 2020. Adiaspores, associated with granulomatous lesions, were observed in ten six-banded (Euphractus sexcinctus) and two southern naked-tailed armadillos (Cabassous unicinctus). A previously uncharacterized Onygenales species was molecularly identified in two E. sexcinctus. In summary, herein we report 12 cases of pulmonary adiaspiromycosis (PA) in two species of free-living armadillos in Brazil. Both, the morphology of the fungus, as well as the histopathological findings (granulomatous inflammatory response to adiaspores) are consistent with PA; however, as the molecular identification differs from the reported species, the potential impact of this fungus for human PA is unknown, and we cannot rule out its impact on public health. (AU)

• Processo FAPESP: 18/25069-7 - Estudo e caracterização de agentes virais emergentes selecionados e potencialmente associados a hepatopatias em cetáceos costeiros, pelágicos e de habitat misto no Brasil
• Beneficiário: Carlos Sacristan Yague
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 17/02223-8 - Imunopatologia comparativa da infecção por Morbillivirus nos cetáceos: estudos histológico, imuno-histoquímico e molecular
• Beneficiário: Josué Díaz Delgado
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado