Chemical Exchanges between Multilateral Symbionts

Autor(es)

Bae, Munhyung ^[1] ; Mevers, Emily ^[1] ; Pishchany, Gleb ^[1] ; Whaley, Sarah G. ^[2] ; Rock, Charles O. ^[2] ; Andes, David R. ^[3] ; Currie, Cameron R. ^[4] ; Pupo, Monica T. ^[5] ; Clardy, Jon ^[1]

Afiliação do(s) autor(es)

^[1] Harvard Med Sch, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 - USA

^[2] St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 - USA

^[3] Univ Wisconsin, Dept Med, Sch Med & Publ Hlth, Madison, WI 53705 - USA

^[4] Univ Wisconsin, Dept Bacteriol, Madison, WI 53706 - USA

^[5] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ORGANIC LETTERS; v. 23, n. 5, p. 1648-1652, MAR 5 2021.
• Citações Web of Science: 0

Resumo

Herein is a report on the molecular exchange occurring between multilateral symbiosis partners-a tit-for-tat exchange that led to the characterization of two new metabolites, conocandin B (fungal-derived) and dentigerumycin F (bacterial-derived). The structures were determined by NMR, mass spectrometry, genomic analysis, and chemical derivatizations. Conocandin B exhibits antimicrobial activity against both the bacterial symbionts of fungus-growing ant and human pathogenic strains by selectively inhibiting FabH, thus disrupting fatty acid biosynthesis. (AU)

• Processo FAPESP: 13/50954-0 - Novos agentes terapêuticos obtidos de bactérias simbiontes de invertebrados brasileiros
• Beneficiário: Mônica Tallarico Pupo
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático