Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Chemical Exchanges between Multilateral Symbionts

Full text
Author(s):
Bae, Munhyung [1] ; Mevers, Emily [1] ; Pishchany, Gleb [1] ; Whaley, Sarah G. [2] ; Rock, Charles O. [2] ; Andes, David R. [3] ; Currie, Cameron R. [4] ; Pupo, Monica T. [5] ; Clardy, Jon [1]
Total Authors: 9
Affiliation:
[1] Harvard Med Sch, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 - USA
[2] St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 - USA
[3] Univ Wisconsin, Dept Med, Sch Med & Publ Hlth, Madison, WI 53705 - USA
[4] Univ Wisconsin, Dept Bacteriol, Madison, WI 53706 - USA
[5] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: ORGANIC LETTERS; v. 23, n. 5, p. 1648-1652, MAR 5 2021.
Web of Science Citations: 0
Abstract

Herein is a report on the molecular exchange occurring between multilateral symbiosis partners-a tit-for-tat exchange that led to the characterization of two new metabolites, conocandin B (fungal-derived) and dentigerumycin F (bacterial-derived). The structures were determined by NMR, mass spectrometry, genomic analysis, and chemical derivatizations. Conocandin B exhibits antimicrobial activity against both the bacterial symbionts of fungus-growing ant and human pathogenic strains by selectively inhibiting FabH, thus disrupting fatty acid biosynthesis. (AU)

FAPESP's process: 13/50954-0 - Novel therapeutic agents from the bacterial symbionts of Brazilian invertebrates
Grantee:Mônica Tallarico Pupo
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants