| Full text | |
| Author(s): |
Bae, Munhyung
[1]
;
Mevers, Emily
[1]
;
Pishchany, Gleb
[1]
;
Whaley, Sarah G.
[2]
;
Rock, Charles O.
[2]
;
Andes, David R.
[3]
;
Currie, Cameron R.
[4]
;
Pupo, Monica T.
[5]
;
Clardy, Jon
[1]
Total Authors: 9
|
| Affiliation: | [1] Harvard Med Sch, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 - USA
[2] St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 - USA
[3] Univ Wisconsin, Dept Med, Sch Med & Publ Hlth, Madison, WI 53705 - USA
[4] Univ Wisconsin, Dept Bacteriol, Madison, WI 53706 - USA
[5] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | ORGANIC LETTERS; v. 23, n. 5, p. 1648-1652, MAR 5 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Herein is a report on the molecular exchange occurring between multilateral symbiosis partners-a tit-for-tat exchange that led to the characterization of two new metabolites, conocandin B (fungal-derived) and dentigerumycin F (bacterial-derived). The structures were determined by NMR, mass spectrometry, genomic analysis, and chemical derivatizations. Conocandin B exhibits antimicrobial activity against both the bacterial symbionts of fungus-growing ant and human pathogenic strains by selectively inhibiting FabH, thus disrupting fatty acid biosynthesis. (AU) | |
| FAPESP's process: | 13/50954-0 - Novel therapeutic agents from the bacterial symbionts of Brazilian invertebrates |
| Grantee: | Mônica Tallarico Pupo |
| Support Opportunities: | BIOTA-FAPESP Program - Thematic Grants |