Non-Syndromic Intellectual Disability and Its Pathways: A Long Noncoding RNA Perspective

Autor(es)

Barros, Isabela I. ^[1] ; Leao, Vitor ^[1] ; Santis, Jessica O. ^[1] ; Rosa, Reginaldo C. A. ^[1] ; Brotto, Danielle B. ^[1] ; Storti, Camila B. ^[1] ; Siena, Adamo D. D. ^[1] ; Molfetta, Greice A. ^[1] ; Silva, Jr., Wilson A. ^{[1, 2, 3, 4, 5, 6]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Genet, Ave Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Natl Inst Sci & Technol Stem Cell & Cell Therapy, Ribeirao Preto Med Sch, Rua Tenente Catao Roxo 2501, BR-14051140 Ribeirao Preto - Brazil

^[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Ctr Cell Based Therapy, Rua Tenente Catao Roxo 2501, BR-14051140 Ribeirao Preto - Brazil

^[4] Univ Sao Paulo, Ribeirao Preto Med Sch, Ctr Integrat Syst Biol CISBi, NAP USP, Rua Catao Roxo 2501, BR-14051140 Ribeirao Preto - Brazil

^[5] Midwest State Univ Parana UNICTR, Dept Med, Rua Fortim Atalaia 1900, Cidade Lagos, BR-85100000 Guarapuava - Brazil

^[6] Guarapuava Inst Canc Res, Rua Fortim Atalaia 1900, Cidade Lagos, BR-85100000 Guarapuava - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: NON-CODING RNA; v. 7, n. 1 MAR 2021.
• Citações Web of Science: 0

Resumo

Non-syndromic intellectual disability (NS-ID or idiopathic) is a complex neurodevelopmental disorder that represents a global health issue. Although many efforts have been made to characterize it and distinguish it from syndromic intellectual disability (S-ID), the highly heterogeneous aspect of this disorder makes it difficult to understand its etiology. Long noncoding RNAs (lncRNAs) comprise a large group of transcripts that can act through various mechanisms and be involved in important neurodevelopmental processes. In this sense, comprehending the roles they play in this intricate context is a valuable way of getting new insights about how NS-ID can arise and develop. In this review, we attempt to bring together knowledge available in the literature about lncRNAs involved with molecular and cellular pathways already described in intellectual disability and neural function, to better understand their relevance in NS-ID and the regulatory complexity of this disorder. (AU)

• Processo FAPESP: 09/53853-5 - Aquisição de uma plataforma de alta performance para análises computacionais aplicadas à medicina
• Beneficiário: Wilson Araújo da Silva Junior
• Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários
• Processo FAPESP: 13/08135-2 - CTC - Centro de Terapia Celular
• Beneficiário: Dimas Tadeu Covas
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs