| Texto completo | |
| Autor(es): |
Pieretti, Joana Claudio
[1]
;
Goncalves, Marcelly Chue
[2]
;
Nakazato, Gerson
[2]
;
Santos de Souza, Ana Carolina
[1]
;
Boudier, Ariane
[3]
;
Seabra, Amedea Barozzi
[1]
Número total de Autores: 6
|
| Afiliação do(s) autor(es): | [1] Fed Univ ABC UFABC, Ctr Nat & Human Sci CCNH, Santo Andre, SP - Brazil
[2] Univ Estadual Londrina, Dept Microbiol, Londrina, PR - Brazil
[3] Univ Lorraine, CITHEFOR, F-54000 Nancy - France
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE; v. 32, n. 3 MAR 2021. |
| Citações Web of Science: | 0 |
| Resumo | |
The combination of Fe3O4@Ag superparamagnetic hybrid nanoparticles and nitric oxide (NO) represents an innovative strategy for a localized NO delivery with a simultaneous antibacterial and antitumoral actions. Here, we report the design of Fe3O4@Ag hybrid nanoparticles, coated with a modified and nitrosated chitosan polymer, able to release NO in a biological medium. After their synthesis, physicochemical characterization confirmed the obtention of small NO-functionalized superparamagnetic Fe3O4@Ag NPs. Antibacterial assays demonstrated enhanced effects compared to control. Bacteriostatic effect against Gram-positive strains and bactericidal effect against E. coli were demonstrated. Moreover, NO-functionalized Fe3O4@Ag NPs demonstrated improved ability to reduce cancer cells viability and less cytotoxicity against non-tumoral cells compared to Fe3O4@Ag NPs. These effects were associated to the ability of these NPs act simultaneous as cytotoxic (necrosis inductors) and cytostatic compounds inducing S-phase cell cycle arrest. NPs also demonstrated low hemolysis ratio (<10%) at ideal work range, evidencing their potential for biomedical applications. {[}GRAPHICS] . (AU) | |
| Processo FAPESP: | 19/07766-5 - Hemocompatibilidade de nanopartículas híbridas de magnetita/prata recobertas com doadores de óxido nítrico |
| Beneficiário: | Joana Claudio Pieretti |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Mestrado |
| Processo FAPESP: | 18/08194-2 - Óleo essencial contendo nanopartículas metálicas funcionalizadas com óxido nítrico como estratégia para o controle de patógenos vegetais na agricultura |
| Beneficiário: | Amedea Barozzi Seabra |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 18/02832-7 - Nanopartículas híbridas magnéticas e antibacterianas: síntese, caracterização e aplicações |
| Beneficiário: | Joana Claudio Pieretti |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |