Platelet activating factor in the eye: Physiological roles, diseases and future perspectives

Autor(es)

Dalmaso, Barbara ^[1] ; da Silva-Junior, Ildefonso Alves ^[2] ; Fragel-Madeira, Lucianne ^[3] ; Jancar, Sonia ^[2] ; Debbio, Carolina Beltrame Del ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Biomed Sci Inst, Dept Cell & Dev Biol, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Biomed Sci Inst, Dept Immunol, Sao Paulo - Brazil

^[3] Fluminense Fed Univ, Inst Biol, Dept Neurobiol, Rio De Janeiro - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Prostaglandins & Other Lipid Mediators; v. 153, APR 2021.
• Citações Web of Science: 0

Resumo

Platelet Activating Factor (PAF) is a known phospholipid mediator of inflammation. Since its first description in 1972, it has emerged as a key regulator of vital cellular signaling functions, as proliferation, cell adhesion, and apoptosis. Evidence suggests that interactions between PAF and its receptor (PAFR) play a critical role in nervous system tissues, including the retina. The retina is a very important constituent of the visual system, along with the cornea, sclera, choroid, iris, and ciliary body, that acts synergistically to provide vision and to maintain optical homeostasis. There is evidence that PAF may regulate a wide range of physiological functions in the visual system tissues, such as eye development, inflammation, epithelial wound healing, and synapsis. Due to their multiple functions, PAF and PAFR also have important pathological and clinical implications in ocular disorders such as Choroidal Neovascularization (CNV), Age Macular Degeneration, (AMD), Diabetic Retinopathy (DR), transplant responses, and pharmacological interactions. Studies with PAFR antagonists have shown promising results such as inhibition of neovascularization and chloroquine-induced retinopathies, as well as reducing inflammation and retinal cell death. Due to the importance of PAFR signaling in the visual system and ophthalmology research, this review aims to provide a general overview of current and future perspectives about PAF in eye biology (AU)

• Processo FAPESP: 19/08544-6 - O papel do receptor do PAF na reprogramação de células-tronco retinianas
• Beneficiário: Bárbara Dalmaso
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 15/24001-1 - Papel dos microRNAs na regulação das células-tronco retinianas
• Beneficiário: Carolina Beltrame Del Debbio
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores