Recent advances in drug discovery against Mycobacterium tuberculosis: Metal-based complexes

Autor(es)

Scarim, Caue Benito ^[1] ; de Farias, Renan Lira ^[2] ; de Godoy Netto, Adelino Vieira ^[2] ; Chin, Chung Man ^{[1, 3]} ; dos Santos, Jean Leandro ^{[2, 1]} ; Pavan, Fernando Rogerio ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, BR-14800903 Araraquara, SP - Brazil

^[2] Sao Paulo State Univ UNESP, Inst Chem, BR-14800900 Araraquara, SP - Brazil

^[3] Union Coll Great Lakes UNILAGO, Sch Med, BR-15030070 Sao Jose Do Rio Preto, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY; v. 214, MAR 15 2021.
• Citações Web of Science: 0

Resumo

Metal-based drugs are privileged motifs that act as primary pharmacophores in bioactive compounds for various diseases, including tuberculosis (TB). This potentially life-threatening and extremely contagious infectious disease is caused by Mycobacterium tuberculosis (Mtb). In 2018, TB infected about 10 million people and caused 1.2 million deaths worldwide. A large number of ligands are promising scaffolds in drug design, including heterocyclic, phosphines, schiff bases, thio and semicarbazones, aliphatic amines, cyclopalladated, cyanometallates and miscellaneous. Moreover, several metal-based complexes have been studied for the treatment of numerous illnesses, including infectious diseases. To contribute to drug design, we identified the metal-based organometallic complexes against Mtb. Thus, in this review article, we analysed the recent contributions of metal-based scaffolds for design of new anti-Mtb drugs in the last decade (2011-2020). Besides, metal-based approaches will be presented in order to find out new antitubercular agents. (C) 2021 Elsevier Masson SAS. All rights reserved. (AU)

• Processo FAPESP: 16/10847-9 - Hidroximetilnitrofural (NFOH): estudo da atividade em fase crônica da Doença de Chagas em modelo animal e síntese de derivados solúveis
• Beneficiário: Cauê Benito Scarim
• Modalidade de apoio: Bolsas no Brasil - Doutorado