Circulating Extracellular Vesicles As Biomarkers and Drug Delivery Vehicles in Cardiovascular Diseases

Autor(es)

de Freitas, Renata Caroline Costa ^{[1, 2]} ; Hirata, Rosario Dominguez Crespo ^[1] ; Hirata, Mario Hiroyuki ^[1] ; Aikawa, Elena ^{[2, 3, 4]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Analyses, BR-05508000 Sao Paulo - Brazil

^[2] Harvard Med Sch, Brigham & Womens Hosp, Ctr Interdisciplinary Cardiovasc Sci, Div Cardiovasc Med, Boston, MA 02115 - USA

^[3] Harvard Med Sch, Brigham & Womens Hosp, Ctr Excellence Vasc Biol, Div Cardiovasc Med, Boston, MA 02115 - USA

^[4] Sechenov First Moscow State Med Univ, Dept Human Pathol, Moscow 119992 - Russia

• Tipo de documento: Artigo de Revisão
• Fonte: BIOMOLECULES; v. 11, n. 3 MAR 2021.
• Citações Web of Science: 0

Resumo

Extracellular vesicles (EVs) are composed of a lipid bilayer containing transmembrane and soluble proteins. Subtypes of EVs include ectosomes (microparticles/microvesicles), exosomes, and apoptotic bodies that can be released by various tissues into biological fluids. EV cargo can modulate physiological and pathological processes in recipient cells through near- and long-distance intercellular communication. Recent studies have shown that origin, amount, and internal cargos (nucleic acids, proteins, and lipids) of EVs are variable under different pathological conditions, including cardiovascular diseases (CVD). The early detection and management of CVD reduce premature morbidity and mortality. Circulating EVs have attracted great interest as a potential biomarker for diagnostics and follow-up of CVD. This review highlights the role of circulating EVs as biomarkers for diagnosis, prognosis, and therapeutic follow-up of CVD, and also for drug delivery. Despite the great potential of EVs as a tool to study the pathophysiology of CVD, further studies are needed to increase the spectrum of EV-associated applications. (AU)

• Processo FAPESP: 19/22147-0 - Avaliação do perfil de microRNA-proteína exossomais em pacientes com hipercolesterolemia familiar
• Beneficiário: Renata Caroline Costa de Freitas
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado