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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Circulating Extracellular Vesicles As Biomarkers and Drug Delivery Vehicles in Cardiovascular Diseases

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Author(s):
de Freitas, Renata Caroline Costa [1, 2] ; Hirata, Rosario Dominguez Crespo [1] ; Hirata, Mario Hiroyuki [1] ; Aikawa, Elena [2, 3, 4]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Analyses, BR-05508000 Sao Paulo - Brazil
[2] Harvard Med Sch, Brigham & Womens Hosp, Ctr Interdisciplinary Cardiovasc Sci, Div Cardiovasc Med, Boston, MA 02115 - USA
[3] Harvard Med Sch, Brigham & Womens Hosp, Ctr Excellence Vasc Biol, Div Cardiovasc Med, Boston, MA 02115 - USA
[4] Sechenov First Moscow State Med Univ, Dept Human Pathol, Moscow 119992 - Russia
Total Affiliations: 4
Document type: Review article
Source: BIOMOLECULES; v. 11, n. 3 MAR 2021.
Web of Science Citations: 0
Abstract

Extracellular vesicles (EVs) are composed of a lipid bilayer containing transmembrane and soluble proteins. Subtypes of EVs include ectosomes (microparticles/microvesicles), exosomes, and apoptotic bodies that can be released by various tissues into biological fluids. EV cargo can modulate physiological and pathological processes in recipient cells through near- and long-distance intercellular communication. Recent studies have shown that origin, amount, and internal cargos (nucleic acids, proteins, and lipids) of EVs are variable under different pathological conditions, including cardiovascular diseases (CVD). The early detection and management of CVD reduce premature morbidity and mortality. Circulating EVs have attracted great interest as a potential biomarker for diagnostics and follow-up of CVD. This review highlights the role of circulating EVs as biomarkers for diagnosis, prognosis, and therapeutic follow-up of CVD, and also for drug delivery. Despite the great potential of EVs as a tool to study the pathophysiology of CVD, further studies are needed to increase the spectrum of EV-associated applications. (AU)

FAPESP's process: 19/22147-0 - Evaluation of exosomal microRNA-protein profile in familial hypercholesterolemia patients
Grantee:Renata Caroline Costa de Freitas
Support Opportunities: Scholarships abroad - Research Internship - Doctorate