A Comparative in Silico Analysis of CD24's Prognostic Value in Human and Canine Prostate Cancer

Autor(es)

Leis-Filho, Antonio Fernando ^[1] ; Lainetti, Patricia de Faria ^[1] ; Franzoni, Mayara Simao ^[1] ; Palmieri, Chiara ^[2] ; Kobayshi, Priscila Emiko ^{[3, 4]} ; Laufer-Amorim, Renee ^[3] ; Fonseca-Alves, Carlos Eduardo ^{[1, 5]}

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Dept Vet Surg & Anim Reprod, BR-18618681 Botucatu, SP - Brazil

^[2] Univ Queensland UQ, Sch Vet Sci, Gatton Campus, Brisbane, Qld 4343 - Australia

^[3] Sao Paulo State Univ UNESP, Dept Vet Clin, BR-18618681 Botucatu, SP - Brazil

^[4] Fac Ensino Super & Formacao Integral FAEF, Lab Patol, BR-17400000 Garca - Brazil

^[5] Paulista Univ UNIP, Inst Hlth Sci, BR-18618681 Bauru, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF PERSONALIZED MEDICINE; v. 11, n. 3 MAR 2021.
• Citações Web of Science: 0

Resumo

CD24 is a cell surface molecule anchored by glycosyl-phosphatidyl-inositol and expressed by different human cancers, including prostate cancer (PC). Some studies have demonstrated that CD24 expression is associated with poor patient outcome; however, few studies have investigated CD24 expression in spontaneous animal models of human PC, such as canine PC. This study aimed to evaluate the expression of CD24 in human PC using the in silico analysis of the data obtained from The Cancer Genome Atlas (TCGA) and comparing it with the previously published prostatic canine transcriptome data. In addition, CD24 expression was confirmed by immunohistochemistry in an independent cohort of canine prostatic samples and its prognostic significance assessed. The systematic review identified 10 publications fitting with the inclusion criteria of this study. Of the 10 manuscripts, 5 demonstrated a direct correlation between CD24 overexpression and patient prognoses. CD24 expression was also associated with PSA relapse (2/5) and tumor progression (1/5). However, the in silico analysis did not validate CD24 as a prognostic factor of human PC. Regarding canine PC, 10 out of 30 normal prostates and 27 out of 40 PC samples were positive for CD24. As in humans, there was no association with overall survival. Overall, our results demonstrated a significant CD24 overexpression in human and canine prostate cancer, although its prognostic value may be questionable. However, tumors overexpressing CD24 may be a reliable model for new target therapies and dogs could be used of a unique preclinical model for these studies. (AU)

• Processo FAPESP: 21/02702-9 - Análise comparativa in silico do valor prognóstico de CD24 no câncer de próstata humano e canino
• Beneficiário: Carlos Eduardo Fonseca Alves
• Modalidade de apoio: Auxílio à Pesquisa - Publicações científicas - Artigo
• Processo FAPESP: 19/00765-3 - Análise comparada do transcriptoma de células prostáticas humanas e caninas para identificar de alvos terapêuticos
• Beneficiário: Carlos Eduardo Fonseca Alves
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado