Ru-90@bio-MOF-1: A ruthenium(II) metallodrug occluded in porous Zn-based MOF as a strategy to develop anticancer agents

Autor(es)

Marson Armando, Renan Augusto ^[1] ; Abucafy, Marina Paiva ^[2] ; Graminha, Angelica Ellen ^[3] ; da Silva, Roberto Santana ^[3] ; Galvao Frem, Regina Celia ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ, UNESP, Inst Chem, Prof Francisco Degnini St 55, Araraquara, SP - Brazil

^[2] Sao Paulo State Univ, UNESP, Sch Pharmaceut Sci, Araraquara, SP - Brazil

^[3] Univ Sao Paulo, USP, Sch Pharmaceut Sci, Cafe Ave, Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Solid State Chemistry; v. 297, MAY 2021.
• Citações Web of Science: 0

Resumo

One of the major challenges in the field of biomedicine is to use biocompatible carriers to achieve efficient drug delivery in the body. Most of the existing carriers have shown poor loading and rapid drug release. In this context, a subclass of coordination polymers, known as Metal-Organic Frameworks (MOFs), has attracted huge research interest the unique physical properties of MOFs make them exceptional materials for drug delivery systems. Here, we have synthesized and characterized a non-toxic Zn-based MOF, designated bio-MOF-1, by using 4,4'-biphenyl-dicarboxylic acid and adenine as linkers. The microcrystalline porous material presented great loading capacity (0.340 g.g(-1)) for the antitumoral metallodrug Ru-90 {[}cis-{[}Ru(bpy)(2)(NO2)(solv)](PF6)]. The cellular viability results demonstrated that metallodrug occlusion facilitated its access and increased its availability in the cells. Ru90 release from bio-MOF-1 depended on pH, so this material is a promising candidate for anticancer drug delivery. Moreover, application of kinetic equation models revealed that the mechanism of Ru-90 release from bioMOF-1 fitted the Korsmeyer-Peppas model for the system at pH 5.0 and pH 7.4; the plots displayed high linearity and correlation coefficient values (R-2) greater than 0.96. The n values were under 0.45 (Korsmeyer-Peppas model), which suggested the quasi Fickian model for the transport mechanism. In conclusion, the kinetic study results showed that bio-MOF-1 delivers the anticancer complex Ru-90 mostly through a diffusive mechanism. (AU)

• Processo FAPESP: 19/19453-1 - Metal-Organic Frameworks (MOFs): síntese modulada e aplicações em catálise, fotônica e sistemas de liberação controlada
• Beneficiário: Regina Celia Galvao Frem
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/13961-0 - BioMOF (Biocompatible Metal-Organic Framework) de zinco como sistema de liberação de metalofármacos com atividade anticancerígena
• Beneficiário: Renan Augusto Marson Armando
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica