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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Low-Dose Coconut Oil Supplementation Induces Hypothalamic Inflammation, Behavioral Dysfunction, and Metabolic Damage in Healthy Mice

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Autor(es):
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Veras, Alana Carolina Costa [1] ; dos Santos, Tamires [1] ; Martins, Isis de Cassia Alves [1] ; de Souza, Camilla Mendes [1] ; Amaral, Camila Libardi [1] ; Franco, Beatriz da Silva [2] ; Holanda, Alessandro Spencer de Souza [2] ; Esteves, Andrea Maculano [2] ; Milanski, Marciane [3, 1] ; Torsoni, Adriana Souza [3, 1] ; Ignacio-Souza, Leticia Martins [3, 1] ; Torsoni, Marcio Alberto [3, 1]
Número total de Autores: 12
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Lab Metab Disorders, Sch Appl Sci, Limeira - Brazil
[2] Univ Estadual Campinas, Sch Appl Sci, Lab Sleep & Exercise, Limeira - Brazil
[3] Univ Estadual Campinas, Obes & Comorbid Res Ctr, Campinas - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: MOLECULAR NUTRITION & FOOD RESEARCH; v. 65, n. 10 APR 2021.
Citações Web of Science: 0
Resumo

Scope Coconut oil (CO) diets remain controversial due to the possible association with metabolic disorder and obesity. This study investigates the metabolic effects of a low amount of CO supplementation. Methods and Results Swiss male mice are assigned to be supplemented orally during 8 weeks with 300 mu L of water for the control group (CV), 100 or 300 mu L of CO (CO100 and CO300) and 100 or 300 mu L of soybean oil (SO; SO100 and SO300). CO led to anxious behavior, increase in body weight gain, and adiposity. In the hypothalamus, CO and SO increase cytokines expression and pJNK, pNFKB, and TLR4 levels. Nevertheless, the adipose tissue presented increases macrophage infiltration, TNF-alpha and IL-6 after CO and SO consumption. IL-1B and CCL2 expression, pJNK and pNFKB levels increase only in CO300. In the hepatic tissue, CO increases TNF-alpha and chemokines expression. Neuronal cell line (mHypoA-2/29) exposed to serum from CO and SO mice shows increased NFKB migration to the nucleus, TNF-alpha, and NFKBia expression, but are prevented by inhibitor of TLR4 (TAK-242). Conclusions These results show that a low-dose CO changes the behavioral pattern, induces inflammatory pathway activation, TLR4 expression in healthy mice, and stimulates the pro-inflammatory response through a TLR4-mediated mechanism. (AU)

Processo FAPESP: 16/23484-1 - Participação de receptores colinérgicos do tipo nicotínico alfa7 (alfa7nAChR) na prevenção do desenvolvimento de resistência à insulina
Beneficiário:Marcio Alberto Torsoni
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 18/01863-6 - Papel do receptor nicotínico colinérgico alfa 7 (alfa7nAChR) no controle hipotalâmico da homeostase energética e associação com a sinalização da leptina em camundongos
Beneficiário:Camilla Mendes de Souza
Modalidade de apoio: Bolsas no Brasil - Mestrado