Short- and Long-Term Social Recognition Memory Are Differentially Modulated by Neuronal Histamine

Autor(es)

Rani, Barbara ^[1] ; Silva-Marques, Bruna ^{[2, 3]} ; Leurs, Rob ^[4] ; Passani, Maria Beatrice ^[1] ; Blandina, Patrizio ^[3] ; Provensi, Gustavo ^[3]

Afiliação do(s) autor(es)

^[1] Univ Florence, Sect Clin Pharmacol & Oncol, Dept Hlth Sci DSS, I-50139 Florence - Italy

^[2] Univ Fed Sao Carlos, Ctr Biol Sci & Hlth, Dept Physiotherapy, BR-905 Sao Carlos, SP - Brazil

^[3] Univ Florence, Sect Pharmacol Toxicol, Dept Neurosci Psychol Drug Res & Child Hlth NEURO, I-50019 Florence - Italy

^[4] Vrije Univ Amsterdam, Fac Sci, Div Med Chem, Amsterdam Inst Mol Med & Syst AIMMS, NL-1081 HZ Amsterdam - Netherlands

• Tipo de documento: Artigo Científico
• Fonte: BIOMOLECULES; v. 11, n. 4 APR 2021.
• Citações Web of Science: 0

Resumo

The ability of recognizing familiar conspecifics is essential for many forms of social interaction including reproduction, establishment of dominance hierarchies, and pair bond formation in monogamous species. Many hormones and neurotransmitters have been suggested to play key roles in social discrimination. Here we demonstrate that disruption or potentiation of histaminergic neurotransmission differentially affects short (STM) and long-term (LTM) social recognition memory. Impairments of LTM, but not STM, were observed in histamine-deprived animals, either chronically (Hdc(-/-) mice lacking the histamine-synthesizing enzyme histidine decarboxylase) or acutely (mice treated with the HDC irreversible inhibitor alpha-fluoromethylhistidine). On the contrary, restriction of histamine release induced by stimulation of the H3R agonist (VUF16839) impaired both STM and LTM. H3R agonism-induced amnesic effect was prevented by pre-treatment with donepezil, an acetylcholinesterase inhibitor. The blockade of the H3R with ciproxifan, which in turn augmented histamine release, resulted in a procognitive effect. In keeping with this hypothesis, the procognitive effect of ciproxifan was absent in both Hdc(-/-) and alpha FMH-treated mice. Our results suggest that brain histamine is essential for the consolidation of LTM but not STM in the social recognition test. STM impairments observed after H3R stimulation are probably related to their function as heteroreceptors on cholinergic neurons. (AU)

• Processo FAPESP: 18/08099-0 - Ativação na Anidrase Carbônica na Extinção do Medo Condicionado em Ratos
• Beneficiário: Bruna Silva Marques
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado