Genetic polymorphisms of the serotonin transporter are not related with depression in temporal lobe epilepsy caused by hippocampal sclerosis

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Vincentiis, Silvia ^[1] ; Alcantara, Juliana A. ^[1] ; Rzezak, Patricia ^[1] ; Kerr, Daniel S. ^[2] ; Gattaz, Wagner F. ^[2] ; van der Linden Jr, Helio ; dos Santos, Bernardo ^[1] ; Arruda, Francisco ^[3] ; Chaim-Avancini, Tiffany ^[4] ; Serpa, Mauricio H. ^[4] ; Fernandes, Fernando ^[5] ; Moreno, Ricardo A. ^[5] ; Busatto, Geraldo F. ^[4] ; Alessi, Ruda ^[1] ; Demarque, Renata ^[1] ; Valente, Kette D. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo HCFMUSP, Hosp Clin, Inst & Dept Psychiat, Lab Clin Neurophysiol, Fac Med, Rua Dr Ovidio Pires de Campos 785, BR-05403010 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo FMUSP, Dept Psychiat, Lab Neurosci LIM 27, Fac Med, Rua Dr Ovidio Pires de Campos 785, BR-05403010 Sao Paulo, SP - Brazil

^[3] van der Linden Jr, Jr., Helio, Goiania Neurol Inst, Praca Gilson Alves de Souza 140, BR-74210250 Goiania, Go - Brazil

^[4] Univ Sao Paulo FMUSP, Dept Psychiat, Lab Psychiat Neuroimaging LIM 21, Fac Med, Rua Dr Ovidio Pires de Campos 785, BR-05403010 Sao Paulo, SP - Brazil

^[5] Univ Sao Paulo HCFMUSP, Hosp Clin, Inst & Dept Psychiat, Mood Disorders Unit GRUDA, Fac Med, Rua Dr Ovidio Pires de Campos 785, BR-05403010 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Epilepsy & Behavior; v. 117, APR 2021.
• Citações Web of Science: 0

Resumo

Background: Mood disorders are the most frequent psychiatric disorders in patients with temporal lobe epilepsy caused by hippocampal sclerosis (TLE-HS). The pathophysiological mechanisms in common between TLE and mood disorders include abnormalities in the serotonergic pathway. We aimed to evaluate the association between serotonin transporter genetic polymorphisms - 5-HTTLPR and 5-HTTVNTR - and the presence of mood disorders in patients with TLE-HS. Methods: We evaluated 119 patients with TLE-HS, with and without psychiatric disorder; 146 patients diagnosed with major depressive disorder (MDD), and 113 healthy volunteers. Individuals were geno-typed for the 5-HTTLPR and 5-HTTVNTR polymorphisms. Results: No difference was observed between the TLE-HS groups, healthy controls, and MDD without epilepsy. There was a correlation between the 12-allele of the 5-HTTVNTR and the family history of patients with epilepsy with TLE-HS (p = 0.013). Conclusions: In this study conducted in two Brazilian centers, the serotonin transporter polymorphisms evaluated cannot be associated with depressive disorder in patients with TLE-HS. Still, they do have some influence over some clinical characteristics of epilepsy in TLE-HS. These data may not be reproduced in other populations with distinct ethnic characteristics. (C) 2021 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 13/11361-4 - Estudo de associação entre polimorfismos de genes da via serotoninérgica e epilepsia do lobo temporal causada por esclerose hipocampal
• Beneficiário: Kette Dualibi Ramos Valente
• Modalidade de apoio: Auxílio à Pesquisa - Regular