What do we Really Know about Nanotoxicology of Silver Nanoparticles In vivo? New Aspects, Possible Mechanisms, and Perspectives

Autor(es)

Duran, Nelson ^{[1, 2, 3, 4]} ; Favaro, Wagner J. ^{[2, 3, 4]} ; Seabra, Amedea B. ^{[1, 2, 4]}

Afiliação do(s) autor(es)

^[1] Fed Univ ABC UFABC, Ctr Nat & Human Sci, Santo Andre, SP - Brazil

^[2] Fed Univ ABC UFABC, Nanomed Res Unit NANOMED, Santo Andre, SP - Brazil

^[3] Univ Estadual Campinas, UNICAMP, Inst Biol, Urogenital Carcinogenesis & Immunotherapy Lab, Dep, Campinas, SP - Brazil

^[4] Univ Estadual Campinas, Lab Nanostruct Synth & Biol Interact NanoBioss, Inst Chem, Campinas, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: CURRENT NANOSCIENCE; v. 17, n. 3, p. 292+, 2021.
• Citações Web of Science: 0

Resumo

Actually, many discussions on the potential risks of silver nanoparticles (AgNPs) have been reported; however, unfortunately, very few considered the great differences between the nature of silver and sources of their syntheses. All data suggested that the effects on toxicity of AgNPs are related to the combination of the specific properties of AgNPs. In this context, this review presents and discusses the recent progress in the nanotoxicity of AgNPs, obtained by different biogenic synthetic protocols, in comparison with chemical synthetic methods, driving to the formation of nanoparticles with diverse structures, and size distributions. Biogenic syntheses of AgNPs using several biological sources and other chemical agents are presented and discussed. Toxicity in different animals is also presented and discussed. By considering the actual state of the art, it can be assumed that oral, intravenous and inhalation doses of AgNPs from 0.1 to 2 mg/Kg in mice and rats are considered a safe administration. In terms of ecotoxicity, it is more concerning since many of the in vivo assays showed a very low lethal dose, i.e., 50% (LD50). Therefore, we have to be very careful with the AgNPs residues in the environment. (AU)

• Processo FAPESP: 18/08194-2 - Óleo essencial contendo nanopartículas metálicas funcionalizadas com óxido nítrico como estratégia para o controle de patógenos vegetais na agricultura
• Beneficiário: Amedea Barozzi Seabra
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/11154-1 - Desenvolvimento de híbridos de óxido de grafeno como plataforma para o tratamento do câncer de bexiga não-músculo invasivo: interações da imunoterapia com Bacillus Calmette-Guérin, metformina e RNA de interferência
• Beneficiário: Joel Gonçalves de Souza
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado