Biomimetic electrochemical sensors: New horizons and challenges in biosensing applications

Autor(es)

Romanholo, Pedro V. V. ^[1] ; Razzino, Claudia A. ^[2] ; Raymundo-Pereira, Paulo A. ^[3] ; Prado, Thiago M. ^[4] ; Machado, Sergio A. S. ^[4] ; Sgobbi, Livia F. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Goias, Inst Quim, BR-74690900 Goiania, Go - Brazil

^[2] Univ Vale Paraiba, Inst Pesquisa & Desenvolvimento, BR-12244000 Sao Jose Dos Campos, SP - Brazil

^[3] Univ Sao Paulo, Inst Fis Sao Carlos, BR-13566690 Sao Carlos, SP - Brazil

^[4] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13566590 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BIOSENSORS & BIOELECTRONICS; v. 185, AUG 1 2021.
• Citações Web of Science: 2

Resumo

The urge to meet the ever-growing needs of sensing technology has spurred research to look for new alternatives to traditional analytical methods. In this scenario, the glucometer is the flagship of commercial electrochemical sensing platforms, combining selectivity, reliability and portability. However, other types of enzyme-based biosensors seldom achieve the market, in spite of the large and increasing number of publications. The reasons behind their commercial limitations concern enzyme denaturation, and the high costs associated with procedures for their extraction and purification. In this sense, biomimetic materials that seek to imitate the desired properties of natural enzymes and biological systems have come out as an appealing path for robust and sensitive electrochemical biosensors. We herein portray the historical background of these biomimicking materials, covering from their beginnings until the most impactful applications in the field of electrochemical sensing platforms. Throughout the discussion, we present and critically appraise the major benefits and the most significant drawbacks offered by the bioinspired systems categorized as Nanozymes, Synzymes, Molecularly Imprinted Polymers (MIPs), Nanochannels, and Metal Complexes. Innovative strategies of fabrication and challenging applications are further reviewed and evaluated. In the end, we ponder over the prospects of this emerging field, assessing the most critical issues that shall be faced in the coming decade. (AU)

• Processo FAPESP: 16/01919-6 - Design e fabricação de dispositivos flexíveis nanoestruturados para detecção de biomarcadores
• Beneficiário: Paulo Augusto Raymundo Pereira
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado