Evaluation of APOE polymorphisms and the risk for age-related macular degeneration in a Southeastern Brazilian population

Autor(es):Mostrar menos -

Viturino, Marina G. M. ^[1] ; Neto, Jamil M. ^[1] ; Bajano, Flavia F. ^[2] ; Costa, Sueli M. S. ^[2] ; Roque, Alicia B. ^[1] ; Borges, Gessica F. S. ^[1] ; Ananina, Galina ^[2] ; Rim, Priscila H. H. ^[1] ; Medina, Flavio M. ^[3] ; Costa, Fernando F. ^[4] ; Vasconcellos, Jose P. C. de ^[1] ; Melo, Monica B. de ^[2]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Dept Ophthalmol, Fac Med Sci, BR-13083887 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Ctr Mol Biol & Genet Engn CBMEG, Lab Human Genet, BR-13083875 Campinas, SP - Brazil

^[3] Univ Estado Rio De Janeiro, Dept Ophthalmol, Fac Med Sci, BR-20551030 Rio De Janeiro, RJ - Brazil

^[4] Univ Estadual Campinas, Hematol & Hemotherapy Ctr, BR-13083878 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Experimental Biology and Medicine; v. 246, n. 10, p. 1148-1155, MAY 2021.
• Citações Web of Science: 0

Resumo

This study aimed to evaluate the role of APOE polymorphisms (rs429358 and rs7412) in the risk of age-related macular degeneration in a sample of the Southeastern Brazilian population. Seven hundred and five unrelated individuals were analyzed, 334 with age-related macular degeneration (case group), and 371 without the disease (control group). In the case group, patients were further stratified according to disease phenotypes, divided into dry and wet age-related macular degeneration, and non-advanced and advanced age-related macular degeneration. APOE polymorphisms (rs429358 and rs7412) were evaluated through polymerase chain reaction and direct sequencing. In the comparison of cases vs. controls, none of the associations reached statistical significance, considering the Bonferroni-adjusted P-value, although there was a suggestive protection for the E3/E4 genotype (OR = 0.626; P-value = 0.037) and E4 carriers (OR = 0.6515; P-value = 0.047). Statistically significant protection for both the E3/E4 genotype and E4 carriers was observed in the comparisons: advanced age-related macular degeneration vs. controls (OR = 0.3665, P-value = 0.491 x 10(-3) and OR = 0.4031, P-value = 0.814 x 10(-3), respectively), advanced age-related macular degeneration vs. non-advanced age-related macular degeneration (OR = 0.2529, P-value = 0.659 x 10(-4) and OR = 0.2692, P-value = 0.631 x 10(-4), respectively). In the comparison of wet age-related macular degeneration vs. control, protection was statistically significant only for E3/E4 (OR = 0.4052, P-value = 0.001). None of the comparisons demonstrated any significant association for E2 genotypes or E2 carriers in age-related macular degeneration risk in this study. Findings suggest a protective role of the E4 haplotype in the APOE gene in the risk for advanced and wet forms of age-related macular degeneration, in a sample of the Brazilian population. To our knowledge, this is the first Brazilian study to show the association between APOE polymorphisms and age-related macular degeneration. (AU)

• Processo FAPESP: 10/18353-9 - Citocinas inflamatórias e associação com o tratamento e etiologia do glaucoma primário de ângulo aberto
• Beneficiário: Mônica Barbosa de Melo
• Modalidade de apoio: Auxílio à Pesquisa - Regular