From purines to purinergic signalling: molecular functions and human diseases

Autor(es):Mostrar menos -

Huang, Zhao ^{[1, 2, 3, 4]} ; Xie, Na ^{[1, 2, 3, 4]} ; Illes, Peter ^{[5, 6]} ; Di Virgilio, Francesco ^[7] ; Ulrich, Henning ^{[8, 5]} ; Semyanov, Alexey ^{[9, 10]} ; Verkhratsky, Alexei ^{[11, 5, 10]} ; Sperlagh, Beata ^[12] ; Yu, Shu-Guang ^{[5, 13]} ; Huang, Canhua ^{[1, 2, 3, 4, 14]} ; Tang, Yong ^{[5, 13]}

Afiliação do(s) autor(es):Mostrar menos -

^[1] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu - Peoples R China

^[2] Sichuan Univ, West China Hosp, Canc Ctr, Chengdu - Peoples R China

^[3] Sichuan Univ, West China Sch Basic Med Sci & Forens Med, Chengdu - Peoples R China

^[4] Collaborat Innovat Ctr Biotherapy, Chengdu - Peoples R China

^[5] Chengdu Univ Tradit Chinese Med, Int Collaborat Ctr Big Sci Plan Purinerg Signalli, Chengdu - Peoples R China

^[6] Univ Leipzig, Rudolf Boehm Inst Pharmakol & Toxikol, Leipzig - Germany

^[7] Univ Ferrara, Dept Med Sci, Ferrara - Italy

^[8] Univ Sao Paulo, Inst Chem, Dept Biochem, Sao Paulo - Brazil

^[9] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow - Russia

^[10] Sechenov First Moscow State Med Univ, Moscow - Russia

^[11] Univ Manchester, Fac Biol Med & Hlth, Manchester, Lancs - England

^[12] Hungarian Acad Sci, Inst Expt Med, Dept Pharmacol, Budapest - Hungary

^[13] Acupuncture & Chronobiol Key Lab Sichuan Prov, Chengdu - Peoples R China

^[14] Chengdu Univ Tradit Chinese Med, Sch Basic Med Sci, Chengdu - Peoples R China

• Tipo de documento: Artigo de Revisão
• Fonte: SIGNAL TRANSDUCTION AND TARGETED THERAPY; v. 6, n. 1 APR 28 2021.
• Citações Web of Science: 5

Resumo

Purines and their derivatives, most notably adenosine and ATP, are the key molecules controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these purines support, as chemical messengers, purinergic transmission throughout tissues and species. Purines act as endogenous ligands that bind to and activate plasmalemmal purinoceptors, which mediate extracellular communication referred to as ``purinergic signalling{''}. Purinergic signalling is cross-linked with other transmitter networks to coordinate numerous aspects of cell behaviour such as proliferation, differentiation, migration, apoptosis and other physiological processes critical for the proper function of organisms. Pathological deregulation of purinergic signalling contributes to various diseases including neurodegeneration, rheumatic immune diseases, inflammation, and cancer. Particularly, gout is one of the most prevalent purine-related disease caused by purine metabolism disorder and consequent hyperuricemia. Compelling evidence indicates that purinoceptors are potential therapeutic targets, with specific purinergic agonists and antagonists demonstrating prominent therapeutic potential. Furthermore, dietary and herbal interventions help to restore and balance purine metabolism, thus addressing the importance of a healthy lifestyle in the prevention and relief of human disorders. Profound understanding of molecular mechanisms of purinergic signalling provides new and exciting insights into the treatment of human diseases. (AU)

• Processo FAPESP: 18/07366-4 - Receptores de purinas e cininas como alvos de estudo e intervenção terapêutica em doenças neurológicas
• Beneficiário: Alexander Henning Ulrich
• Modalidade de apoio: Auxílio à Pesquisa - Temático