Preventive oral kefir supplementation protects mice from ovariectomy-induced exacerbated allergic airway inflammation

Autor(es)

Mendes, E. ^[1] ; Casaro, M. B. ^[1] ; Fukumori, C. ^[1] ; Ribeiro, W. R. ^[1] ; dos Santos, A. L. ^[2] ; Sartorelli, P. ^[2] ; Lazarini, M. ^[1] ; Bogsan, C. S. B. ^[3] ; Oliveira, M. A. ^[4] ; Ferreira, C. M. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Inst Environm Chem & Pharmaceut Sci, Dept Pharmaceut Sci, R Sao Nicolau 210, BR-0991303 Diadema, SP - Brazil

^[2] Univ Fed Sao Paulo, Inst Environm Chem & Pharmaceut Sci, Chem Dept, BR-09972270 Diadema, SP - Brazil

^[3] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Biochem Pharmaceut Technol, Av Prof Lineu Prestes 580, B-16, BR-05508900 Sao Paulo, SP - Brazil

^[4] Univ Sao Paulo, Inst Biomed Sci 1, Dept Pharmacol, Av Prof Lineu Prestes 1374, BR-05508000 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BENEFICIAL MICROBES; v. 12, n. 2, p. 187-197, 2021.
• Citações Web of Science: 0

Resumo

Asthma is an inflammatory lung disease that affects more women than men in adulthood. Clinical evidence shows that hormonal fluctuation during the menstrual cycle and menopause are related to increased asthma severity in women. Considering that life expectancy has increased and that most women now undergo menopause, strategies to prevent the worsening of asthma symptoms are particularly important. A recent study from our group showed that re-exposure of ovariectomised allergic mice to antigen (ovalbumin) leads to an exacerbation of lung inflammation that is similar to clinical conditions. However, little is known about the role of probiotics in the prevention of asthma exacerbations during the menstrual cycle or menopause. Thus, our objective was to evaluate the effects of supplementation with kefir, a popular fermented dairy beverage, as a preventive strategy for modulating allergic disease. The results show that the preventive kefir administration decreases the influx of inflammatory cells in the airways and exacerbates the production of mucus and the interleukin 13 cytokine. Additionally, kefir changes macrophage polarisation by decreasing the number of M2 macrophages, as shown by RT-PCR assay. Thus, kefir is a functional food that potentially prevents allergic airway inflammation exacerbations in ovariectomised mice. (AU)

• Processo FAPESP: 12/50410-8 - Efeito dos ácidos graxos de cadeia curta produzidos por bactérias probióticas na profilaxia e tratamento da inflamação alérgica das vias aéreas
• Beneficiário: Caroline Marcantonio Ferreira
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 16/13496-2 - Papel da administração de simbióticos no período perinatal na asma alérgica experimental da prole
• Beneficiário: Mateus Campos Casaro
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica