Casaro, M. B.
Ribeiro, W. R.
dos Santos, A. L.
Bogsan, C. S. B.
Oliveira, M. A.
Ferreira, C. M.
Total Authors: 10
 Univ Fed Sao Paulo, Inst Environm Chem & Pharmaceut Sci, Dept Pharmaceut Sci, R Sao Nicolau 210, BR-0991303 Diadema, SP - Brazil
 Univ Fed Sao Paulo, Inst Environm Chem & Pharmaceut Sci, Chem Dept, BR-09972270 Diadema, SP - Brazil
 Univ Sao Paulo, Fac Pharmaceut Sci, Dept Biochem Pharmaceut Technol, Av Prof Lineu Prestes 580, B-16, BR-05508900 Sao Paulo, SP - Brazil
 Univ Sao Paulo, Inst Biomed Sci 1, Dept Pharmacol, Av Prof Lineu Prestes 1374, BR-05508000 Sao Paulo, SP - Brazil
Total Affiliations: 4
Web of Science Citations:
Asthma is an inflammatory lung disease that affects more women than men in adulthood. Clinical evidence shows that hormonal fluctuation during the menstrual cycle and menopause are related to increased asthma severity in women. Considering that life expectancy has increased and that most women now undergo menopause, strategies to prevent the worsening of asthma symptoms are particularly important. A recent study from our group showed that re-exposure of ovariectomised allergic mice to antigen (ovalbumin) leads to an exacerbation of lung inflammation that is similar to clinical conditions. However, little is known about the role of probiotics in the prevention of asthma exacerbations during the menstrual cycle or menopause. Thus, our objective was to evaluate the effects of supplementation with kefir, a popular fermented dairy beverage, as a preventive strategy for modulating allergic disease. The results show that the preventive kefir administration decreases the influx of inflammatory cells in the airways and exacerbates the production of mucus and the interleukin 13 cytokine. Additionally, kefir changes macrophage polarisation by decreasing the number of M2 macrophages, as shown by RT-PCR assay. Thus, kefir is a functional food that potentially prevents allergic airway inflammation exacerbations in ovariectomised mice. (AU)