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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Preventive oral kefir supplementation protects mice from ovariectomy-induced exacerbated allergic airway inflammation

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Mendes, E. [1] ; Casaro, M. B. [1] ; Fukumori, C. [1] ; Ribeiro, W. R. [1] ; dos Santos, A. L. [2] ; Sartorelli, P. [2] ; Lazarini, M. [1] ; Bogsan, C. S. B. [3] ; Oliveira, M. A. [4] ; Ferreira, C. M. [1]
Total Authors: 10
[1] Univ Fed Sao Paulo, Inst Environm Chem & Pharmaceut Sci, Dept Pharmaceut Sci, R Sao Nicolau 210, BR-0991303 Diadema, SP - Brazil
[2] Univ Fed Sao Paulo, Inst Environm Chem & Pharmaceut Sci, Chem Dept, BR-09972270 Diadema, SP - Brazil
[3] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Biochem Pharmaceut Technol, Av Prof Lineu Prestes 580, B-16, BR-05508900 Sao Paulo, SP - Brazil
[4] Univ Sao Paulo, Inst Biomed Sci 1, Dept Pharmacol, Av Prof Lineu Prestes 1374, BR-05508000 Sao Paulo, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: BENEFICIAL MICROBES; v. 12, n. 2, p. 187-197, 2021.
Web of Science Citations: 0

Asthma is an inflammatory lung disease that affects more women than men in adulthood. Clinical evidence shows that hormonal fluctuation during the menstrual cycle and menopause are related to increased asthma severity in women. Considering that life expectancy has increased and that most women now undergo menopause, strategies to prevent the worsening of asthma symptoms are particularly important. A recent study from our group showed that re-exposure of ovariectomised allergic mice to antigen (ovalbumin) leads to an exacerbation of lung inflammation that is similar to clinical conditions. However, little is known about the role of probiotics in the prevention of asthma exacerbations during the menstrual cycle or menopause. Thus, our objective was to evaluate the effects of supplementation with kefir, a popular fermented dairy beverage, as a preventive strategy for modulating allergic disease. The results show that the preventive kefir administration decreases the influx of inflammatory cells in the airways and exacerbates the production of mucus and the interleukin 13 cytokine. Additionally, kefir changes macrophage polarisation by decreasing the number of M2 macrophages, as shown by RT-PCR assay. Thus, kefir is a functional food that potentially prevents allergic airway inflammation exacerbations in ovariectomised mice. (AU)

FAPESP's process: 12/50410-8 - Effects of short-chain fatty acids produced by probiotic bacteria in the prophylaxis and treatment of allergic airway inflammation
Grantee:Caroline Marcantonio Ferreira
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 16/13496-2 - Symbiotic administration's role in the perinatal period in experimental allergic asthma in offspring
Grantee:Mateus Barbosa Casaro
Support type: Scholarships in Brazil - Scientific Initiation