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Symbiotic administration's role in the perinatal period in experimental allergic asthma in offspring

Grant number: 16/13496-2
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2016
Effective date (End): October 31, 2019
Field of knowledge:Biological Sciences - Immunology - Cellular Immunology
Principal Investigator:Caroline Marcantonio Ferreira
Grantee:Mateus Barbosa Casaro
Home Institution: Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil

Abstract

The current scientific scenario indicates a close relationship between the gut microbiota and asthma, based on genetic evidence, environmental factors, and the hygiene hypothesis. The formation of the intestinal microbiota is influenced by the type of delivery, breastfeeding, and nutrition. One of the possible mechanisms involved in the relationship between intestinal microbiota and asthma is the production of short-chain fatty acids (SCFA) by bacteria of the intestinal microbiota. The SCFA activate the GPR43 receptor on leukocytes, activate polymorphonuclear cells, dendritic cells and lymphocytes, and they show anti-inflammatory effect. Knowing that the intestinal microbiota and their metabolic products influence the immune system is important to worry about their formation and composition because it can prevent or inhibit the development of allergic asthma. This study aims to determine whether the administration of fermentable fiber and probiotics, which is symbiotic, the parents during the perinatal period exert some influence on the development of asthma in their offspring in two different strains of mice: A / J and C57BL / 6. These two strains have TH2 inflammatory responses of different intensities and different intestinal microbiota. The main objective of the project is to evaluate the use of symbionts in the perinatal period, influence on the development of experimental allergic asthma of puppies and understand if this influence is mediated by the gut microbiota through the production of fatty acids short-chain and also understand the genetic influence of the host in the formation of intestinal microflora.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FUKUMORI, CLAUDIO; CASARO, MATEUS B.; THOMAS, ANDREW M.; MENDES, EDUARDO; RIBEIRO, WILLIAN R.; CRISMA, AMANDA R.; MURATA, GILSON M.; BIZZARRO, BRUNA; DIAS-NETO, EMMANUEL; SETUBAL, JOAO C.; OLIVEIRA, MARIA A.; TAVARES-DE-LIMA, WOTHAN; CURI, RUI; BORDIN, SILVANA; SARTORELLI, PATRICIA; FERREIRA, CAROLINE M. Maternal supplementation with a synbiotic has distinct outcomes on offspring gut microbiota formation in A/J and C57BL/6 mice, differentially affecting airway inflammatory cell infiltration and mucus production. Journal of Functional Foods, v. 61, OCT 2019. Web of Science Citations: 1.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.