Effects of short-chain fatty acids produced by probiotic bacteria in the prophylax...
| Grant number: | 12/50410-8 |
| Support type: | Research Grants - Young Investigators Grants |
| Duration: | June 01, 2013 - May 31, 2018 |
| Field of knowledge: | Biological Sciences - Physiology |
| Principal Investigator: | Caroline Marcantonio Ferreira |
| Grantee: | Caroline Marcantonio Ferreira |
| Home Institution: | Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil |
| Associated scholarship(s): | 14/03879-6 - Gut microbiota and experimental allergic asthma in C57BL/6 and A/J mice: genetic and fiber intake influence,
BP.IC 13/06265-6 - Role of acetate on experimental allergic asthma: short fatty acid chain productiong probiotic bacteria as a mechanism of action, BP.IC 13/09473-9 - Effects of short-chain fatty acids produced by probiotic bacteria in the prophylaxis and treatment of allergic airway inflammation, BP.JP |
Abstract
Asthma is a chronic inflammatory lung disease that affects 300 million people worldwide. Genetic and environmental factors have been associated with triggering the disease. One od the most environmental factors, it is the exposure to microbes in early life (enviromental factor) that protects against allergies, called as hygiene hypothesis. Since this theory was proposed, many studies have investigated the role of intestinal micro-biota on the modulation of the immune system, and allergy. Studies have shown differences in the composition of the micro-flora between healthy and allergic infants in countries with a high and low prevalence of allergies and between healthy and allergic infants within such countries. Alongside the scientific findings about the importance of the intestinal micro-biota in the prevalence of allergic diseases, probiotics market is expanding with promises of prevention of allergic diseases like asthma. However, it is unclear the effects and mechanisms of probiotic use in the prevention and treatment of asthma. Evidences in the literature also support the possibility that short chain: fatty acids produced by some intestinal bacteria, as acetate, it has anti-inflammatory effects. Moreover, animals deficient GPR43, important receptor to acetate, have an exaggerated inflammatory response models of colitis, arthritis and asthma. The p hypothesis of the present study is that probiotic bacteria could modulate Th2 immune responses via production of short chain fatty acids, such as acetate. We will use two different probiotics, B. longum and B. adolescentis to better investigate the role of short fatty acids produced by probiotics on allergic diseases. The choice of the two species was based on the fact that one is associated with allergy protection and produces more acetate (B. longum) and B. adolescentis it is not associated with allergy protection and it is not a relevant acetate producer. (AU)
| Articles published in Agência FAPESP Newsletter about the research grant |
| Probiotics reduce pulmonary inflammation in cases of asthma |