Short-Term Strength Exercise Reduces Hepatic Insulin Resistance in Obese Mice by Reducing PTP1B Content, Regardless of Changes in Body Weight

Autor(es):Mostrar menos -

da Cruz Rodrigues, Kellen Cristina ^[1] ; Pereira, Rodrigo Martins ^[1] ; Peruca, Guilherme Francisco ^[1] ; Torres Barbosa, Lucas Wesley ^[2] ; Sant'Ana, Marcella Ramos ^[3] ; Munoz, Vitor Rosetto ^[2] ; Morelli, Ana Paula ^[4] ; Simabuco, Fernando Moreira ^[4] ; Ramos da Silva, Adelino Sanchez ^[5] ; Cintra, Dennys Esper ^[3] ; Ropelle, Eduardo Rochete ^[2] ; Pauli, Jose Rodrigo ^[2] ; de Moura, Leandro Pereira ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Fac Appl Sci, Exercise Cell Biol Lab, 1300 Pedro Zaccaria St, BR-13484350 Limeira, SP - Brazil

^[2] Univ Estadual Campinas, Fac Appl Sci, Lab Mol Biol Exercise, 1300 Pedro Zaccaria St, BR-13484350 Limeira, SP - Brazil

^[3] Univ Estadual Campinas, Sch Appl Sci, Lab Nutr Genom, 1300 Pedro Zaccaria St, BR-13484350 Limeira, SP - Brazil

^[4] Univ Estadual Campinas, UNICAMP, Multidisciplinary Lab Food & Hlth, Fac Appl Sci FCA, BR-13484350 Limeira, SP - Brazil

^[5] Univ Sao Paulo, Sch Phys Educ & Sport Ribeirao Preto, 3900 Bandeirantes Ave, BR-14040907 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 22, n. 12 JUN 2021.
• Citações Web of Science: 0

Resumo

Obesity is closely related to insulin resistance and type 2 diabetes genesis. The liver is a key organ to glucose homeostasis since insulin resistance in this organ increases hepatic glucose production (HGP) and fasting hyperglycemia. The protein-tyrosine phosphatase 1B (PTP1B) may dephosphorylate the IR and IRS, contributing to insulin resistance in this organ. Aerobic exercise is a great strategy to increase insulin action in the liver by reducing the PTP1B content. In contrast, no study has shown the direct effects of strength training on the hepatic metabolism of PTP1B. Therefore, this study aims to investigate the effects of short-term strength exercise (STSE) on hepatic insulin sensitivity and PTP1B content in obese mice, regardless of body weight change. To achieve this goal, obese Swiss mice were submitted to a strength exercise protocol lasting 15 days. The results showed that STSE increased Akt phosphorylation in the liver and enhanced the control of HGP during the pyruvate tolerance test. Furthermore, sedentary obese animals increased PTP1B content and decreased IRS-1/2 tyrosine phosphorylation; however, STSE was able to reverse this scenario. Therefore, we conclude that STSE is an important strategy to improve the hepatic insulin sensitivity and HGP by reducing the PTP1B content in the liver of obese mice, regardless of changes in body weight. (AU)

• Processo FAPESP: 16/12569-6 - Efeitos de diferentes intensidades do exercício físico no metabolismo da clusterina e sua interferência na sinalização da insulina em roedores
• Beneficiário: Rodrigo Martins Pereira
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 15/07199-2 - Papel da clusterina/ApoJ na sinalização da insulina em resposta ao exercício físico em roedores e em humanos
• Beneficiário: Leandro Pereira de Moura
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores