Validation of the Donkey Pain Scale (DOPS) for Assessing Postoperative Pain in Donkeys

Autor(es)

Oliveira, Maria Glaucia Carlos de ^[1] ; Paula, Valeria Veras de ^[1] ; Mouta, Andressa Nunes ^[1] ; Lima, Isabelle de Oliveira ^[1] ; Macedo, Lua Barbalho de ^[1] ; Nunes, Talyta Lins ^[2] ; Trindade, Pedro Henrique Esteves ^[3] ; Luna, Stelio Pacca Loureiro ^[3]

Afiliação do(s) autor(es)

^[1] Semiarido Fed Rural Univ UFERSA, Dept Anim Sci, Mossoro - Brazil

^[2] Fed Univ Bahia UFBA, Dept Anat Pathol & Vet Clin, Salvador, BA - Brazil

^[3] Sao Paulo State Univ Unesp, Sch Vet Med & Anim Sci, Dept Vet Surg & Anim Reprod, Botucatu, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN VETERINARY SCIENCE; v. 8, JUN 11 2021.
• Citações Web of Science: 0

Resumo

This study aimed to validate a scale for assessing acute pain in donkeys. Forty-four adult donkeys underwent castration after sedation with intravenous (IV) xylazine, induction with guaifenesin and thiopental IV, local anesthetic block, and maintenance with isoflurane. The scale was constructed from a pilot study with four animals combined with algetic behaviors described for equines. After content validation, the scale was evaluated in 40 other donkeys by three blinded and one reference evaluator, by means of edited videos referring to the preoperative and postoperative periods: before anesthesia, 3-4 h after recovery from anesthesia, 5-6 h after recovery from anesthesia (2 h after analgesia with flunixin-1.1 mg/kg, dipyrone-10 mg/kg, and morphine-0.2 mg/kg) IV, and 24 h after recovery. Content validity, sensitivity, specificity, and responsiveness of behaviors were investigated to refine the scale. Intra- and inter-evaluator reliabilities were investigated by the weighted kappa coefficient, criterion validity by comparing the scale with the visual analog scale (VAS), internal consistency by Cronbach's alpha coefficient, item-total correlation by the Spearman coefficient, and intervention point for rescue analgesic by the receiver operating characteristics curve and Youden index. The scale showed very good intra-evaluator reliability (0.88-0.96), good to moderate (0.56-0.66) inter-evaluator reliability, responsiveness for all items, good criterion validity vs. VAS (0.75), acceptable internal consistency (0.64), adequate item-total correlation, except for head position and direction, and according to the principal component analysis, good association among items. The accuracy of the point for rescue analgesic was excellent (area under the curve = 0.91). The rescue analgesic score was >= 4 of 11 points. The scale can diagnose and quantify acute pain in donkeys submitted to castration, as the instrument is reliable and valid, with a defined intervention analgesic score. (AU)

• Processo FAPESP: 17/12815-0 - Dor e qualidade de vida em animais
• Beneficiário: Stelio Pacca Loureiro Luna
• Modalidade de apoio: Auxílio à Pesquisa - Temático