First complete genome sequence and molecular characterization of Canine morbillivirus isolated in Central Brazil

Autor(es)

da Costa, Vivaldo Gomes ^[1] ; Saivish, Marielena Vogel ^[2] ; de Oliveira, Priscila Gomes ^[3] ; Silva-Junior, Abelardo ^[4] ; Moreli, Marcos Lazaro ^[5] ; Kruger, Ricardo Henrique ^[1]

Afiliação do(s) autor(es)

^[1] Univ Brasilia, Dept Cell Biol, Enzymol Lab, Brasilia, DF - Brazil

^[2] Fac Med Sao Jose do Rio Preto, Dept Dermatol Infect & Parasit Dis, Sao Paulo - Brazil

^[3] Univ Fed Jatai, Inst Agr Sci, Vet Lab, Jatai, Go - Brazil

^[4] Univ Fed Vicosa, Dept Vet, Lab Immunobiol & Anim Virol, Vicosa, MG - Brazil

^[5] Univ Fed Jatai, Inst Hlth Sci, Virol Lab, Jatai, Go - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 11, n. 1 JUN 22 2021.
• Citações Web of Science: 0

Resumo

The Brazilian regions are still highly endemic areas for Canine morbillivirus {[}canine distemper virus (CDV)]. However, little is known regarding the genetic variability of the strain circulating in several Brazilian regions. Here, we report the first full-length genome and molecular characterization of CDV isolated from domestic dogs in the Brazilian Center-West region. Sequence alignment and phylogenetic analyses based on deduced amino acid and nucleotide sequences showed that the isolated strain is characterized as the South America-I/Europe genotype. However, it segregates into a CDV subgenotype branch. Interestingly, both H and F proteins have a gain of a potential N-glycosylation sites compared to the Onderstepoort vaccine strain. Therefore, this study provides a reference to further understand the epidemic and molecular characteristics of the CDV in Brazil. (AU)

• Processo FAPESP: 20/12875-5 - Desenvolvimento de método de diagnóstico para o vírus Rocio e utilização de compostos novos como inibidores da NS2B-NS3 protease-helicase de flavivirus
• Beneficiário: Marielena Vogel Saivish
• Modalidade de apoio: Bolsas no Brasil - Doutorado