Taurine supplementation in conjunction with exercise modulated cytokines and improved subcutaneous white adipose tissue plasticity in obese women

Autor(es):Mostrar menos -

De Carvalho, Flavia Giolo ^[1] ; Cunha Brandao, Camila Fernanda ^{[2, 3]} ; Munoz, Vitor Rosetto ^[4] ; Batitucci, Gabriela ^[5] ; de Almeida Tavares, Maria Eduarda ^[6] ; Teixeira, Giovana Rampazzo ^[6] ; Pauli, Jose Rodrigo ^[4] ; De Moura, Leandro Pereira ^[4] ; Ropelle, Eduardo Rochete ^[4] ; Cintra, Dennys Esper ^[7] ; Ramos da Silva, Adelino Sanchez ^[1] ; Morandi Junqueira-Franco, Marcia Varella ^[2] ; Marchini, Julio Sergio ^[2] ; De Freitas, Ellen Cristini ^{[1, 5]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo EEFERP USP, Sch Phys Educ & Sport Ribeirao Preto, Av Bandeirantes 3900, Vila Monte Alegre, BR-14040907 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo FMRP USP, Ribeirao Preto Med Sch, Internal Med Dept, Ribeirao Preto, SP - Brazil

^[3] State Univ Minas Gerais UEMG, Divinopolis Unit, Minas Gerais - Brazil

^[4] Univ Campinas FCA UNICAMP, Lab Mol Biol Exercise, Limeira, SP - Brazil

^[5] Sao Paulo State Univ FCFAR UNESP, Dept Food & Nutr, Sch Pharmaceut Sci Araraquara, Araraquara, SP - Brazil

^[6] Sao Paulo State Univ UNESP, Dept Phys Educ, Sch Technol & Sci, Presidente Prudente, SP - Brazil

^[7] Univ Campinas FCA UNICAMP, Lab Nutr Genom, Limeira, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Amino Acids; v. 53, n. 9 JUL 2021.
• Citações Web of Science: 0

Resumo

Interventions that can modulate subcutaneous white adipose tissue (scWAT) function, such as exercise training and nutritional components, like taurine, modulate the inflammatory process, therefore, may represent strategies for obesity treatment. We investigated the effects of taurine supplementation in conjunction with exercise on inflammatory and oxidative stress markers in plasma and scWAT of obese women. Sixteen obese women were randomized into two groups: Taurine supplementation group (Tau, n = 8) and Taurine supplementation + exercise group (Tau + Exe, n = 8). The intervention was composed of daily taurine supplementation (3 g) and exercise training for 8 weeks. Anthropometry, body fat composition, and markers of inflammatory and oxidative stress were determined in plasma and scWAT biopsy samples before and after the intervention. We found that, although taurine supplementation increased taurine plasma levels, no changes were observed for the anthropometric characteristics. However, Tau alone decreased interleukin-6 (IL-6), and in conjunction with exercise (Tau + Exe), increased anti-inflammatory interleukins (IL-15 and IL10), followed by reduced IL1 beta gene expression in the scWAT of obese women. Tau and Tau + Exe groups presented reduced adipocyte size and increased connective tissue and multilocular droplets. In conclusion, taurine supplementation in conjunction with exercise modulated levels of inflammatory markers in plasma and scWAT, and improved scWAT plasticity in obese women, promoting protection against obesity-induced inflammation. TRN NCT04279600 retrospectively registered on August 18, 2019. (AU)

• Processo FAPESP: 17/08036-5 - Efeitos da suplementação de taurina associada ou não a prática de exercício concorrente sobre a função mitocondrial, gasto energético e perfil inflamatório de mulheres obesas
• Beneficiário: Flávia Giolo de Carvalho
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 17/10080-2 - Metabolismo energético mitocondrial, inflamação e estresse oxidativo em mulheres obesas submetidas a suplementação de taurina associado ao treinamento físico
• Beneficiário: Ellen Cristini de Freitas
• Modalidade de apoio: Auxílio à Pesquisa - Regular