| Texto completo | |
| Autor(es): |
Rodrigues Tavares, Ligia Renata
[1, 2]
;
Pelarin, Vinicius
[1, 2]
;
Baptista-de-Souza, Daniela
[1, 3, 4]
;
Pereira Ferrari, Daniele
[1]
;
Nunes-de-Souza, Ricardo Luiz
[2, 3, 4]
;
Canto-de-Souza, Azair
[1, 2, 4, 5]
Número total de Autores: 6
|
| Afiliação do(s) autor(es): | [1] Univ Fed Sao Carlos UFSCar, Dept Psychol, Psychobiol Grp, CECH, BR-13565905 Sao Carlos, SP - Brazil
[2] UNESP, Joint Grad Program Physiol Sci UFSCar, Sao Carlos - Brazil
[3] Univ Estadual Paulista UNESP, Sch Pharmaceut Sci, Lab Pharmacol, Araraquara, SP - Brazil
[4] Neurosci & Behav Inst IneC, Ribeirao Preto - Brazil
[5] Program Psychol UFSCar, Sao Carlos - Brazil
Número total de Afiliações: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Social Neuroscience; JUL 2021. |
| Citações Web of Science: | 0 |
| Resumo | |
Cohabitation with a partner undergoing chronic pain induces pain hypersensitivity. Among a lot of other neurochemical pathways, the serotonin (5-HT) role, specifically the 5-HT3 receptor (5-HT3R), in the amygdala has never been evaluated in this model. Here we studied the effects of the amygdala's chemical inhibition, its neuronal activation pattern, and 5-HT, 5-HIAA, and 5-HT turnover within the amygdala. Furthermore, the systemic and intra-amygdala 5-HT3R activation and blockade in mice that cohabited with a conspecific subjected to chronic constriction injury were investigated. Male Swiss mice were housed in partners for 28 days. The dyads were divided into two groups on the 14(th) day: cagemate nerve constriction (CNC) and cagemate sham (CS). On the 24(th) day, cagemates underwent a stereotaxic surgery (when necessary) and, on the 28(th) day, they were evaluated on the writhing test. The amygdala inactivation promotes pain-hypersensitivity behaviors in groups and dyads; cohabitation with a partner with chronic pain did not change FosB-labeled cells in the amygdala's nucleus and increases 5-HT turnover in cagemates. Systemic and intra-amygdala 5-HT3R activation attenuated and enhanced the number of writhes, respectively. In contrast, 5-HT3R blockade reduced hypersensitivity pain response. Results suggest the involvement of amygdala serotonergic signaling via 5-HT3R in empathy-like behavior. (AU) | |
| Processo FAPESP: | 12/22238-6 - Empatia em camungongos: papel da amídala, insula e córtex cingulado anterior na modulação de respostas nociceptivas |
| Beneficiário: | Vinícius Pelarin Do Nascimento Costa |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 17/25409-0 - Mecanismos neurobiológicos subjacentes à lateralidade funcional do córtex pré-frontal medial nas reações de defesa induzidas pelo estresse de derrota social em camundongos |
| Beneficiário: | Ricardo Luiz Nunes de Souza |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 15/15335-3 - Avaliação do papel dos receptores 5-HT3 sobre a resposta nociceptiva de camundongos submetidos ao modelo de empatia para dor |
| Beneficiário: | Daniele Pereira Ferrari |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |