| Texto completo | |
| Autor(es): |
Santana, Lauriana Alves
[1]
;
Moreira Bezerra, Suellen Karoline
[2]
;
Saraiva-Romanholo, Beatriz Mangueira
[3, 2, 4]
;
Yamaguti, Wellington Pereira
[1]
;
Lopes Calvo Tiberio, Iolanda de Fatima
[2]
;
dos Santos, Tabata Maruyama
[2, 1]
;
Righetti, Renato Fraga
[2, 1]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] Hosp Sirio Libanes, Serv Reabilitacao, Rua Adma Jafet, 115 Serv Reabilitacao 4 Andar, BR-01308050 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Med FMUSP, Sao Paulo - Brazil
[3] Univ City Sao Paulo UNICID, Sao Paulo - Brazil
[4] Sao Paulo Hosp IAMSPE, Sao Paulo - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | SCIENTIFIC REPORTS; v. 11, n. 1 JUL 12 2021. |
| Citações Web of Science: | 0 |
| Resumo | |
Some clinical situations require the use of oxygen therapy for a few hours without hypoxemia. However, there are no literature reports on the effects of acute oxygen therapy on the nasal mucosa. This study aimed to evaluate the acute effects of cold bubble humidification or dry oxygen on nasal Inflammation, oxidative stress, mucociliary clearance, and nasal symptoms. This is a randomized controlled cross-sectional study in which healthy subjects were randomly allocated into four groups: (1) CA+DRY (n=8): individuals receiving dry compressed air; (2) OX+DRY (n=8): individuals receiving dry oxygen therapy; (3) CA+HUMID (n=7): individuals receiving cold bubbled humidified compressed air; (4) OX+HUMID (n=8): individuals receiving cold bubbled humidified oxygen therapy. All groups received 3 L per minute (LPM) of the oxygen or compressed air for 1 h and were evaluated: total and differential cells in the nasal lavage fluid (NLF), exhaled nitric oxide (eNO), 8-iso-PGF2 alpha levels, saccharin transit test, nasal symptoms, and humidity of nasal cannula and mucosa. Cold bubble humidification is not able to reduced nasal inflammation, eNO, oxidative stress, mucociliary clearance, and nasal mucosa moisture. However, subjects report improvement of nasal dryness symptoms (P<0.05). In the conclusion, cold bubble humidification of low flow oxygen therapy via a nasal cannula did not produce any effect on the nasal mucosa and did not attenuate the oxidative stress caused by oxygen. However, it was able to improve nasal symptoms arising from the use of oxygen therapy. (AU) | |
| Processo FAPESP: | 18/02537-5 - Caracterização da síndrome de sobreposição asma-DPOC (ACOS): estudos experimentais e clínicos |
| Beneficiário: | Iolanda de Fátima Lopes Calvo Tibério |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |