High compliance and effective treatment of fish endoparasitic infections with oral drug delivery nanobioparticles: Safety of intestinal tissue and blood parameters

Autor(es)

Madrid, Rafael R. M. ^[1] ; Mertins, Omar ^[1] ; Tavares-Dias, Marcos ^[2] ; Flores-Gonzales, Anai P. ^[3] ; C.M.F. Patta, Ana ^[1] ; Ramirez, Carlos A. B. ^[1] ; Rigoni, Vera L. S. ^[1] ; Mathews, Patrick D. ^[1]

Afiliação do(s) autor(es)

^[1] Fed Univ Sao Paulo UNIFESP, Paulista Med Sch, Dept Biophys, Lab Nano Bio Mat LNBM, BR-04023062 Sao Paulo - Brazil

^[2] Embrapa Amapa, Macapa - Brazil

^[3] Inst Res Peruvian Amazon IIAP AQUAREC, Puerto Maldonado - Peru

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF FISH DISEASES; v. 44, n. 11 AUG 2021.
• Citações Web of Science: 1

Resumo

Parasite infections in fish require constant surveillance and strategies for efficient treatments which guarantee the fish health, their sale value and the non-propagation of pathogens in new environments. Fish treatments based on nanotechnology become of increasing interest since nanoparticles have been shown as efficient materials for optimizing administration of bioactives. In this study a chitosan derivative, alginate and praziquantel conjugated nanobioparticle of effective action for oral treatment of digenetic trematodes in highly infected Corydoras schwartzi was evaluated in terms of histological and hematological safety. The inherent absence of alterations in intestinal tissue and the reversible blood cells counting during a period up to 35 days showed the safety of the drug delivery nanobioparticles, which thus represent a promising strategy for effective applications in pathogens treatments by oral administration. (AU)

• Processo FAPESP: 15/23948-5 - Aperfeiçoamento das propriedades do polissacarídeo quitosana para aplicação em lipossomas e vesículas gigantes
• Beneficiário: Omar Mertins
• Modalidade de apoio: Auxílio à Pesquisa - Regular