TEMPO-oxidized cellulose poly-ionic drawn fiber, a cell support system proof of concept

Autor(es)

Rios, Mariana Alves ^[1] ; Barbugli, Paula Aboud ^[2] ; Costa Iemma, Monica Rosas ^[1] ; Grande, Rafael ^[3] ; Felix Carvalho, Antonio Jose ^[4] ; Trovatti, Eliane ^[1]

Afiliação do(s) autor(es)

^[1] Univ Araraquara, UNIARA, R Carlos Gomes 1217, BR-14801340 Araraquara, SP - Brazil

^[2] Sao Paulo State Univ Unesp, Fac Dent, Dept Dent Mat & Prosthodont, Lab Confocal Microscopy, Araraquara, SP - Brazil

^[3] Aalto Univ, Dept Bioprod & Biosyst, Sch Chem Engn, Espoo 00076 - Finland

^[4] Univ Sao Paulo, Sao Carlos Sch Engn, Dept Mat Engn, Av Joao Dagnone 1100, BR-13563120 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Materials Science; v. 56, n. 29 AUG 2021.
• Citações Web of Science: 0

Resumo

The development of new cell carrier systems is crucial for application in regenerative medicine, once they deliver the cells to the injured tissue to trigger the repair and stimulate the regeneration. Here we report the preparation of a cell carrier system in fiber shape, in which the cells osteo-1 are incorporated. For the fiber formation, the oxidized cellulose nanofibers suspension loaded with cells is complexed with calcium ions in a pulling process giving rise to the fiber loaded with cells, with dimensions which allow it to handle. The microscopic images showed the success of the proposed method to incorporate the cells into the fibers. The results of the in vitro viability tests indicated the capability of the fibers to keep the cells alive and to mineralize them, indicating that their osteogenic capability was not affected. In addition, the fiber disintegration studies showed the system is capable of releasing the cells, suggesting the potential of the fibers as a new assembled hydrogel carrier cell therapy. (AU)

• Processo FAPESP: 17/18782-6 - Plataforma click chemistry aplicada ao desenvolvimento de materiais poliméricos para uso em medicina regenerativa
• Beneficiário: Eliane Trovatti
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 18/06555-8 - Produção de hidrogel de celulose quimicamente modificada para bioimpressão
• Beneficiário: Mariana Alves Rios
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica