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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

TEMPO-oxidized cellulose poly-ionic drawn fiber, a cell support system proof of concept

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Author(s):
Rios, Mariana Alves [1] ; Barbugli, Paula Aboud [2] ; Costa Iemma, Monica Rosas [1] ; Grande, Rafael [3] ; Felix Carvalho, Antonio Jose [4] ; Trovatti, Eliane [1]
Total Authors: 6
Affiliation:
[1] Univ Araraquara, UNIARA, R Carlos Gomes 1217, BR-14801340 Araraquara, SP - Brazil
[2] Sao Paulo State Univ Unesp, Fac Dent, Dept Dent Mat & Prosthodont, Lab Confocal Microscopy, Araraquara, SP - Brazil
[3] Aalto Univ, Dept Bioprod & Biosyst, Sch Chem Engn, Espoo 00076 - Finland
[4] Univ Sao Paulo, Sao Carlos Sch Engn, Dept Mat Engn, Av Joao Dagnone 1100, BR-13563120 Sao Carlos, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Journal of Materials Science; v. 56, n. 29 AUG 2021.
Web of Science Citations: 0
Abstract

The development of new cell carrier systems is crucial for application in regenerative medicine, once they deliver the cells to the injured tissue to trigger the repair and stimulate the regeneration. Here we report the preparation of a cell carrier system in fiber shape, in which the cells osteo-1 are incorporated. For the fiber formation, the oxidized cellulose nanofibers suspension loaded with cells is complexed with calcium ions in a pulling process giving rise to the fiber loaded with cells, with dimensions which allow it to handle. The microscopic images showed the success of the proposed method to incorporate the cells into the fibers. The results of the in vitro viability tests indicated the capability of the fibers to keep the cells alive and to mineralize them, indicating that their osteogenic capability was not affected. In addition, the fiber disintegration studies showed the system is capable of releasing the cells, suggesting the potential of the fibers as a new assembled hydrogel carrier cell therapy. (AU)

FAPESP's process: 17/18782-6 - Click chemistry platform for the development of polymer-based materials for regenerative medicine
Grantee:Eliane Trovatti
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 18/06555-8 - Preparation of chemically modified cellulose hydrogel for bioprinting
Grantee:Mariana Alves Rios
Support Opportunities: Scholarships in Brazil - Scientific Initiation