Metabolic syndrome and unfavorable outcomes on body composition and in visceral adiposities indexes among early breast cancer women post-chemotherapy

Autor(es)

da Silva, Bruna Ramos ^[1] ; Rufato, Sarah ^[1] ; Mialich, Mirele S. ^[1] ; Cruz, Loris P. ^[2] ; Gozzo, Thais ^[2] ; Jordao, Alceu A. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Hlth Sci, Ribeirao Preto Med Sch, 3900 Bandeirantes Ave, Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Nursing Sch Ribeirao Preto, 3900 Bandeirantes Ave, Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CLINICAL NUTRITION ESPEN; v. 44, p. 306-315, AUG 2021.
• Citações Web of Science: 0

Resumo

Purpose: The study objected to investigate potential changes in metabolic, dietary, and nutritional status in women with stages I-III breast cancer exposed to chemotherapy. Methods: Women who were starting chemotherapy with no previous treatment were recruited. Anthropometrics, bioelectrical impedance analysis, handgrip strength, blood pressure and blood sample were collected. Visceral adiposity index and lipid accumulation product were calculated. Dietary intake was evaluated, and the multiple source methods program was applied. Metabolic syndrome (MetS) was assessed following the NCEP-ATP III criteria (defined as 3 of 5 components of MetS). All data were collected at 2-time points: diagnosis (T0) and after 1 month of completion of therapy (T1). Mean, standard deviation, percentage, and ANOVA in SAS Studio (R) were used to explore the results. Results: 61 women were included. We did not find any changes in anthropometrics and body composition. However, phase angle, extracellular water (EX) and ratio EX to total body water had expressive changes (p < 0.001). The results showed changes in lipid profile (p < 0.001), and greater unfavorable outcomes on adiposities index (p < 0.001). At the end of the study, 68,8% (N = 42) of the women developed MetS post-chemotherapy. Conclusion: We have found supporting evidence for chemotherapy treatment resulting in worsening of nutritional markers, lipid profile and adiposity markers. After chemotherapy part of the sample developed MetS, even without changes in body weight, fat mass, and food intake. Breast cancer patients may benefit from targeted interventions before starting chemotherapy to prevent MetS post-treatment, and therefore reduce the risk of cardiovascular disease. Further investigation into this theme is needed. (C) 2021 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 19/09877-9 - Maximização dos resultados de pacientes com câncer de mama metastático usando dieta e exercício
• Beneficiário: Bruna Ramos da Silva
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado Direto
• Processo FAPESP: 17/07963-0 - Avaliação do perfil metabólico, oxidativo e antropométrico em mulheres com Câncer de Mama
• Beneficiário: Bruna Ramos da Silva
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto