Bioactivity and composition of lipophilic metabolites extracted from Antarctic macroalgae

Autor(es)

Berneira, Lucas M. ^[1] ; de Santi, Ivandra I. ^[1] ; da Silva, Caroline C. ^[1] ; Venzke, Dalila ^[1] ; Colepicolo, Pio ^[2] ; Vaucher, Rodrigo de A. ^[3] ; dos Santos, Marco A. Z. ^[1] ; de Pereira, Claudio M. P. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Pelotas, Ctr Chem Pharmaceut & Food Sci, Lipidom & Bioorgan Lab, Bioforens Res Grp, Eliseu Maciel St S-N, BR-96900010 Pelotas, RS - Brazil

^[2] State Univ Sao Paulo, Inst Chem, Dept Biochem, Lineu Prestes Av 748, BR-05508000 Sao Paulo, SP - Brazil

^[3] Univ Fed Pelotas, Ctr Chem Pharmaceut & Food Sci, Biochem Res & Mol Biol Microorganisms Lab, Eliseu Maciel St S-N, BR-96900010 Pelotas, RS - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Microbiology; v. 52, n. 3, p. 1275-1285, SEP 2021.
• Citações Web of Science: 1

Resumo

Macroalgae comprise a vast group of aquatic organisms known for their richness in phytochemicals. In this sense, the lipophilic profile of five Antarctic seaweed species was characterized by chromatographic and spectroscopic analysis and their antioxidant and antimicrobial potential was evaluated. Results showed there were 31 lipophilic substances, mainly fatty acids (48.73 +/- 0.77 to 331.91 +/- 10.79 mg.Kg(-1)), sterols (14.74 +/- 0.74 to 321.25 +/- 30.13 mg.Kg(-1)), and alcohols (13.07 +/- 0.04 to 91.87 +/- 30.07 mg.Kg(-1)). Moreover, Desmarestia confervoides had strong antioxidant activity, inhibiting 86.03 +/- 1.47% of the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical at 1 mg.mL(-1). Antimicrobial evaluation showed that extracts from Ulva intestinalis, Curdiea racovitzae, and Adenocystis utricularis inhibited the growth of Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 25923), and Salmonella typhimurium (ATCC 14028) from concentrations of 1.5 to 6 mg.mL(-1). Therefore, the evaluated brown, red, and green macroalgae contained several phytochemicals with promising biological activities that could be applied in the pharmaceutical, biotechnological, and food industries. (AU)

• Processo FAPESP: 10/50193-1 - Estudos de bioprospecção de macroalgas marinhas, uso da biomassa algal como fonte de novos fármacos e bioativos economicamente viáveis e sua aplicação na remediação de áreas impactadas. (Biodiversidade marinha)
• Beneficiário: Pio Colepicolo Neto
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático