| Texto completo | |
| Autor(es): |
Pereira da Silva-Junior, Francisco
[1, 2]
;
dos Santos Alves, Camila Oliveira
[1]
;
Cesar Azevedo Silva, Sonia Maria
[3, 4]
;
Borges, Vanderci
[3]
;
Ferraz, Henrique Ballalai
[3]
;
Guimaraes Rocha, Maria Sheila
[5]
;
Papaterra Limongi, Joao Carlos
[2]
;
Barbosa, Egberto Reis
[2]
;
Aguiar, Patricia de Carvalho
[1, 3]
Número total de Autores: 9
|
| Afiliação do(s) autor(es): | [1] Hosp Israelita Albert Einstein, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Dept Neurol, Sao Paulo, SP - Brazil
[3] Univ Fed Sao Paulo, Dept Neurol & Neurosurg, Sao Paulo, SP - Brazil
[4] Hosp Servidor Publ Estadual, Sao Paulo, SP - Brazil
[5] Hosp Santa Marcelina, Sao Paulo, SP - Brazil
Número total de Afiliações: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NEUROLOGICAL SCIENCES; v. 43, n. 2 JUL 2021. |
| Citações Web of Science: | 0 |
| Resumo | |
Background Although abnormal movements and postures are the hallmark of dystonia, non-motor symptoms (NMS) are common and negatively affect quality of life.ObjectivesThe aim of this study was to screen dystonia patients for NMS and analyze their association with clinical parameters, including motor disability. Methods Adult patients with idiopathic isolated dystonia were interviewed and examined. Dystonia severity was evaluated with the Fahn-Marsden Dystonia Rating Scale and the presence of NMS was assessed using a list of 29 complaints. Results A hundred and two patients (63.7% female) were enrolled. Dystonia began after 20 years of age in 61.8% and was focal or segmental in 82.8% of patients. Only eight patients (7.8%) had no NMS and 59.8% reported more than five. The most prevalent NMS were pain (72.5%) and anxiety (63.7%), followed by difficulty recalling information (44.1%), sadness/anhedonia (41.2%), and difficulty falling asleep (38.2%). No correlation was found between the total number of NMS and dystonia severity (p=0.18) or regular botulinum toxin use (p=0.66). The majority of NMS domains correlated with each other. Conclusions Our results confirm a high prevalence of NMS among dystonia patients, even in those with mild motor disability. The pathophysiology of NMS in dystonia remains to be completely understood. (AU) | |
| Processo FAPESP: | 14/17128-2 - Rede brasileira para o estudo das distonias: estudo de variantes em novos genes (GNAL, CIZ1, ANO3, e TUBB4) em pacientes com distonia idiopática |
| Beneficiário: | Patrícia Maria de Carvalho Aguiar |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |