luronic-loaded Silver Nanoparticles/Photosensitizers Nanohybrids: Influence of the Polymer Chain Length on Metal-enhanced Photophysical Propertie

Autor(es)

Mota, Danielle Ramos ^[1] ; Silva Lima, Giovanni Alexsander ^[1] ; Moises de Oliveira, Hueder Paulo ^[2] ; Pellosi, Diogo Silva ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Chem, Lab Hybrid Mat, Diadema, SP - Brazil

^[2] Fed Univ ABC, Ctr Nat & Human Sci, LACOMB, Santo Andre, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Photochemistry and Photobiology; v. 98, n. 1, SI AUG 2021.
• Citações Web of Science: 1

Resumo

Silver nanoparticles (AgNPs) are incredibly versatile nanostructures that more recently have been exploited to create advanced optoelectronic materials due enhancement of local magnetic field after its irradiation. However, the use of AgNPs as nanoantennas to amplify photophysical properties of close photosensitizer (PS) molecules in photodynamic therapy is still underexplored. The reason for that is the difficulty to control crucial parameters such as silver-PS distance in aqueous solution. In this scenario, here we propose a nanohybrid system where AgNP/PS distance is controlled by a thin layer of different Pluronic copolymers. The controllable distance and aqueous stability of proposed nanohybrids allow a tunable enhancement of fluorescence emission and singlet oxygen generation of some selected PS molecules. A detailed mechanism investigation demonstrated that the observed metal-enhanced photophysics is due to magnetic field enhancement close to AgNP surface (AgNP/PS distance-controlled effect) and the resonant coupling of AgNP hot electrons and HOMO-LUMO energies of the PS (AgNP/PS spectral overlap-controlled effect). These results show that the rational design in engineering new nanohybrid structures allowed photophysical improvement of PS molecules in aqueous solution in a tunable way and point out Pluronic-based AgNP/PS nanohybrids as a smart material for further developments aiming at theranostic applications in photodynamic therapy. (AU)

• Processo FAPESP: 19/01604-3 - Síntese assistida por luz visível de nanohíbridos de nanopartícula de prata/fotossensibilizadores em matriz polimérica e sua aplicação sinérgica em fototerapia
• Beneficiário: Diogo Silva Pellosi
• Modalidade de apoio: Auxílio à Pesquisa - Regular