Pseudoboehmite as a drug delivery system for acyclovir

Autor(es)

Peres, Renato Meneghetti ^[1] ; Leme Sousa, Jessica Maiara ^[1] ; de Oliveira, Mariana Oliva ^[2] ; Rossi, Maura Vincenza ^[1] ; de Oliveira, Rene Ramos ^[3] ; de Lima, Nelson Batista ^[3] ; Bernussi, Ayrton ^{[4, 5]} ; Warzywoda, Juliusz ^[6] ; Sarmento, Bruno ^{[7, 8]} ; Munhoz Jr, Antonio Hortencio

Afiliação do(s) autor(es)

^[1] Univ Prebiteriana Mackenzie, Sch Engn, Rua Consolacao 930, Bldg 33, BR-01302907 Sao Paulo, SP - Brazil

^[2] Univ Prebiteriana Mackenzie, CCBS, Sao Paulo - Brazil

^[3] IPEN, Sao Paulo, SP - Brazil

^[4] Texas Tech Univ, Dept Elect & Comp Engn, Lubbock, TX 79409 - USA

^[5] Texas Tech Univ, Nano Tech Ctr, Lubbock, TX 79409 - USA

^[6] Texas Tech Univ, Whitacre Coll Engn, Mat Characterizat Ctr, Lubbock, TX 79409 - USA

^[7] Univ Porto, INEB Inst Engn Biomed, Porto - Portugal

^[8] Univ Porto, i3S Inst Invest & Inovacao Saude, Porto - Portugal

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 11, n. 1 JUL 29 2021.
• Citações Web of Science: 0

Resumo

Herpes simplex virus is among the most prevalent sexually transmitted infections. Acyclovir is a potent, selective inhibitor of herpes viruses and it is indicated for the treatment and management of recurrent cold sores on the lips and face, genital herpes, among other diseases. The problem of the oral bioavailability of acyclovir is limited because of the low permeability across the gastrointestinal membrane. The use of nanoparticles of pseudoboehmite as a drug delivery system in vitro assays is a promising approach to further the permeability of acyclovir release. Here we report the synthesis of high purity pseudoboehmite from aluminium nitrate and ammonium hydroxide containing nanoparticles, using the sol-gel method, as a drug delivery system to improve the systemic bioavailability of acyclovir. The presence of pseudoboehmite nanoparticles were verified by infrared spectroscopy, transmission electron microscopy, and X-ray diffraction techniques. In vivo tests were performed with Wistar rats to compare the release of acyclovir, with and without the addition of pseudoboehmite. The administration of acyclovir with the addition of pseudoboehmite increased the drug content by 4.6 times in the plasma of Wistar rats after 4 h administration. We determined that the toxicity of pseudoboehmite is low up to 10 mg/mL, in gel and the dried pseudoboehmite nanoparticles. (AU)

• Processo FAPESP: 17/22396-4 - "síntese de nanoparticulas de pseudoboemita"
• Beneficiário: Antonio Hortencio Munhoz Junior
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 10/19157-9 - Síntese de pseudoboemitas modificadas visando à obtenção de nanosistemas para liberação controlada de fármacos
• Beneficiário: Antonio Hortencio Munhoz Junior
• Modalidade de apoio: Auxílio à Pesquisa - Regular