Protein acetylation in the critical biological processes in protozoan parasites

Autor(es)

Maran, Suellen Rodrigues ^[1] ; Fleck, Krista ^[2] ; Monteiro-Teles, Natalia Melquie ^[3] ; Isebe, Tony ^[4] ; Walrad, Pegine ^[3] ; Jeffers, Victoria ^[2] ; Cestari, Igor ^{[5, 4]} ; Vasconcelos, Elton J. R. ^[6] ; Moretti, Nilmar ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo UNIFESP, Escola Paulista Med, Dept Microbiol Imunol & Parasitol, Lab Biol Mol Patogenos LBMP, Sao Paulo - Brazil

^[2] Univ New Hampshire, Dept Mol Cellular & Biomed Sci, Durham, NH 03824 - USA

^[3] Univ York, Dept Biol, York Biomed Res Inst, York, N Yorkshire - England

^[4] McGill Univ, St Anne De Bellevue, Inst Parasitol, Quebec City, PQ - Canada

^[5] McGill Univ, Div Expt Med, Montreal, PQ - Canada

^[6] Univ Leeds, Leeds Omics, Leeds, W Yorkshire - England

• Tipo de documento: Artigo de Revisão
• Fonte: Trends in Parasitology; v. 37, n. 9, p. 815-830, SEP 2021.
• Citações Web of Science: 0

Resumo

Protein lysine acetylation has emerged as a major regulatory post-translational modification in different organisms, present not only on histone proteins affecting chromatin structure and gene expression but also on nonhistone proteins involved in several cellular processes. The same scenario was observed in protozoan parasites after the description of their acetylomes, indicating that acetylation might regulate crucial biological processes in these parasites. The demonstration that glycolytic enzymes are regulated by acetylation in protozoans shows that this modification might regulate several other processes implicated in parasite survival and adaptation during the life cycle, opening the chance to explore the regulatory acetylation machinery of these parasites as drug targets for new treatment development. (AU)

• Processo FAPESP: 19/13765-1 - Caracterização da N-acetiltransferase NAT10 de Leishmania
• Beneficiário: Suellen Rodrigues Maran
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 18/09948-0 - Estudo da acetilação proteica em Leishmania
• Beneficiário: Nilmar Silvio Moretti
• Modalidade de apoio: Auxílio à Pesquisa - Regular