Myrtenol complexed with beta-cyclodextrin ameliorates behavioural deficits and reduces oxidative stress in the reserpine-induced animal model of Parkinsonism

Autor(es):Mostrar menos -

Silva-Martins, Suellen ^[1] ; Araujo Beserra-Filho, Jose Ivo ^[1] ; Maria-Macedo, Amanda ^[1] ; Custodio-Silva, Ana Claudia ^[1] ; Soares-Silva, Beatriz ^[1] ; Silva, Sara Pereira ^[1] ; Lambertucci, Rafael Herling ^[1] ; Silva, Regina Helena ^[2] ; Dos Santos, Jose Ronaldo ^[3] ; Gandhi, Sathiyabama Rajiv ^[4] ; Quintans-Junior, Lucindo Jose ^[4] ; Ribeiro, Alessandra Mussi ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Biosci, Santos, SP - Brazil

^[2] Univ Fed Sao Paulo, Dept Pharmacol, Sao Paulo - Brazil

^[3] Univ Fed Sergipe, Dept Biosci, Aracaju - Brazil

^[4] Univ Fed Sergipe, Dept Physiol, Itabaiana - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Clinical and Experimental Pharmacology and Physiology; v. 48, n. 11 AUG 2021.
• Citações Web of Science: 0

Resumo

Current pharmacological approaches to treat Parkinson's disease have low long-term efficacy and important adverse side effects. The development of new pharmacological therapies has focused on novel plant-derived phytochemicals. The alcoholic monoterpene myrtenol has been isolated from several plant species, and has anxiolytic, analgesic, anti-inflammatory and antioxidant actions. Our study evaluated the neuroprotective potential of myrtenol complexed with beta-cyclodextrin (MYR) on a progressive parkinsonism model induced by reserpine (RES) in mice. The complexation with cyclodextrins enhances the pharmacological action of monoterpenes. Male Swiss mice were treated daily with MYR (5 mg/kg, p.o.) and with RES (0.1 mg/kg, s.c.) every other day during 28 days. Behavioural evaluations were conducted across treatment. At the end of the treatment, immunohistochemistry for tyrosine hydroxylase (TH) and oxidative stress parameters were evaluated. Chronic MYR-treatment protected against olfactory sensibility loss, restored short-term memory and decreased RES-induced motor impairments. Moreover, this treatment prevented dopaminergic depletion and reduced the oxidative status index in the dorsal striatum. Therefore, MYR ameliorated motor and non-motor impairments in the progressive animal model of parkinsonism, possibly by an antioxidant action. Additional research is needed to investigate the mechanisms involved in this neuroprotective effect. (AU)

• Processo FAPESP: 18/26609-5 - Investigação do potencial efeito neuroprotetor do mirtenol complexado com ²-ciclodextrina em um modelo animal progressivo da Doença de Parkinson
• Beneficiário: Suellen Silva Martins
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica