Synthetic Strategies for the (+)-Grandisol, the Main Constituent of Boll Weevil Pheromone

Autor(es)

Santos, Krysthal Marrie dos ^[1] ; Neto, Jorge de Lima ^[1] ; Silva, Luis Paulo Alves da ^[1] ; Reis, Analu Campos ^[1] ; Porto, Ricardo Silva ^[1] ; Lima, Dimas Jose da Paz ^[1] ; Santana, Antonio Euzebio Goulart ^[2]

Afiliação do(s) autor(es)

^[1] Univ Fed Alagoas, Chem & Biotechnol Inst, Maceio, Alagoas - Brazil

^[2] Univ Fed Alagoas, Ctr Engn & Agr Sci, Rio Largo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: MINI-REVIEWS IN ORGANIC CHEMISTRY; v. 18, n. 6, p. 690-708, 2021.
• Citações Web of Science: 0

Resumo

This paper presents a short review of synthetic approaches aiming to synthesise (+)Grandisol, the main constituent of grandlure, a pheromone mixture released by the boll weevil, which is proven to exhibit significant biological activity. (+)-Grandisol 1 is among the components of the male-produced pheromone of the boll weevil Anthonomuns grandis, an important pest of cotton crops in Mesoamerica (from the south USA to Argentina). As a result of its biological activity and unique structure, several synthetic approaches have been reported. The aim is to explore remarkable methodologies towards the synthesis of (+)-Grandisol 1. Several methodologies have been applied towards the synthesis of (+)-Grandisol 1, including classical methods for cyclobutane ring construction, which promoted substantial improvements to access this pheromone, as well as a better comprehension of its biological profile. (AU)

• Processo FAPESP: 14/50871-0 - INCT 2014: Instituto Nacional de Ciência Tecnologia de Semioquímicos na Agricultura
• Beneficiário: José Roberto Postali Parra
• Modalidade de apoio: Auxílio à Pesquisa - Temático