Daily and LPS-induced variation of endocrine mediators in cururu toads (Rhinella icterica)

Autor(es)

Oliveira Bastos, Priscilla Rachel ^[1] ; Monteiro Titon, Stefanny Christie ^[1] ; Titon Junior, Braz ^[1] ; Gomes, Fernando Ribeiro ^[1] ; Markus, Regina P. ^[1] ; Ferreira, Zulma S. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Biociencias, Dept Fisiol, Rua Matao, Trav 14, 101, BR-05505090 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CHRONOBIOLOGY INTERNATIONAL; v. 39, n. 1 SEP 2021.
• Citações Web of Science: 1

Resumo

Increased plasma glucocorticoids (corticosterone - CORT, in amphibians) and melatonin (MEL) are associated with the daily activity phase and with environmental darkness, respectively. Besides, CORT and MEL also play pivotal immunomodulatory roles in several vertebrates. Herein we described the daily profile of plasma MEL and CORT for Rhinella icterica toads in captivity. Thereafter, we investigated the effects of lipopolysaccharide (LPS)-induced systemic inflammation on the production of CORT and MEL in the R. icterica. Captive toads showed CORT and MEL diurnal variation typical of nocturnal species, with increased values for CORT at ZT12 (18 h) and MEL peak at ZT18 (24 h). LPS-induced hormonal changes included increased plasma CORT and decreased ocular and plasma MEL when compared to those from toads treated with saline 2 h post-injection. Our results demonstrated the presence of a diurnal CORT and MEL variation in toads. We also showed the crosstalk between CORT and MEL during the toad's systemic inflammation in response to an immune challenge with LPS. Additionally, our results demonstrated that anuran eyes' MEL production might be regulated during the inflammatory processes. (AU)

• Processo FAPESP: 13/13691-1 - Eixo imune-pineal: integrando a biologia do tempo em condições fisiológicas, fisiopatológicas e patológicas
• Beneficiário: Regina Pekelmann Markus
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 13/00900-1 - Estudo comparativo das relações entre imunocompetência e níveis plasmáticos de esteróides inter-renais e gonadais em sapos
• Beneficiário: Fernando Ribeiro Gomes
• Modalidade de apoio: Auxílio à Pesquisa - Regular