Characteristics of TIMP1, CD63, and beta 1-Integrin and the Functional Impact of Their Interaction in Cancer

Autor(es)

Justo, Beatriz Lais ^[1] ; Jasiulionis, Miriam Galvonas ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo UNIFESP, Dept Pharmacol, Escola Paulista Med, Rua Pedro Toledo 669, 5 Floor, BR-04039032 Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 22, n. 17 SEP 2021.
• Citações Web of Science: 0

Resumo

Tissue Inhibitor of Metalloproteases 1, also known as TIMP-1, is named for its well-established function of inhibiting the proteolytic activity of matrix metalloproteases. Given this function, many studies were carried out to verify if TIMP-1 was able to interrupt processes such as tumor cell invasion and metastasis. In contrast, many studies have shown that TIMP-1 expression is increased in several types of tumors, and this increase was correlated with a poor prognosis and lower survival in cancer patients. Later, it was shown that TIMP-1 is also able to modulate cell behavior through the induction of signaling pathways involved in cell growth, proliferation, and survival. The mechanisms involved in the regulation of the pleiotropic functions of TIMP-1 are still poorly understood. Thus, this review aimed to present literature data that show its ability to form a membrane complex with CD63 and beta 1-integrin, and point to N-glycosylation as a potential regulatory mechanism of the functions exerted by TIMP-1. This article reviewed the characteristics and functions performed individually by TIMP1, CD63, and beta 1-integrin, the roles of the TIMP-1/CD63/beta 1-integrin complex, both in a physiological context and in cancer, and the regulatory mechanisms involved in its assembly. (AU)

• Processo FAPESP: 20/01211-9 - Análise da glicosilação N-aberrante de TIMP1 e seu papel na progressão do melanoma
• Beneficiário: Beatriz Laís Justo Saraiva
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 18/20775-0 - RNAs não codificantes envolvidos com a gênese e a progressão do melanoma
• Beneficiário: Miriam Galvonas Jasiulionis
• Modalidade de apoio: Auxílio à Pesquisa - Regular