Clinical, functional and inflammatory evaluation in asthmatic patients after a simple short-term educational program: a randomized trial

Autor(es):Mostrar menos -

Felix, Soraia Nogueira ^[1] ; Agondi, Rosana Camara ^[2] ; Aun, Marcelo Vivolo ^[2] ; Olivo, Clarice Rosa ^{[3, 1, 4]} ; de Almeida, Francine Maria ^[4] ; Amorim, Thais Santos ^[3] ; Cezario, Julia Caroline ^[3] ; Giavina-Bianchi, Pedro ^[2] ; Tiberio, Iolanda de Fatima Lopes Calvo ^[4] ; de Martins, Milton de Arruda ^[4] ; Romanholo, Beatriz Mangueira Saraiva ^{[3, 1, 4]}

Afiliação do(s) autor(es)

^[1] Inst Assistencia Medica Ao Servidor Publico, Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, HCFMUSP, Serv Imunol Clin Alergia, Sao Paulo, SP - Brazil

^[3] Univ Cidade Sao Paulo UNICID, Sao Paulo, SP - Brazil

^[4] Univ Sao Paulo, Fac Med USP FMUSP, Lab Terapeut Expt LIM 20, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 11, n. 1 SEP 14 2021.
• Citações Web of Science: 0

Resumo

This study aimed to evaluate the clinical evolution, functional parameters and inflammatory activity of asthma in patients who submitted to an educational intervention. 58 adult patients over 18 years of age with partly controlled and uncontrolled asthma were randomized into an intervention group (IG) (N = 32) and a control group (CG) (N = 26) and evaluated for 12 weeks. The Asthma Control Test (ACT), Asthma Control Questionnaire (ACQ), Asthma Quality Life Questionnaire (AQLQ) and Beck Depression Inventory (BDI) questionnaires were applied. Spirometry, exhaled nitric oxide (NO), exhaled breath condensate (EBC) and induced sputum (IS), measurement of the peak flow and symptoms were performed. The IG patients received an educational activity for 30 min applied by a nurse. Statistical analysis: analysis of variance with repeated intragroup measures. IG presented a decreased number of eosinophils in IS and IL-17A in EBC, an increase in the percentage of FEV1 before and after bronchodilator and an improvement in quality of life compared to the CG. There was an improvement in depression levels and a decrease in IL-4 and IL-5 in the IS and in the EBC in both groups. Our results suggest that an educational intervention can bring benefits concerning the control of inflammation, lung function alterations, quality of life and levels of depression in asthmatic patients. Registration: ClinicalTrials.gov; NCT03655392. (AU)

• Processo FAPESP: 14/26829-4 - Avaliação clínica, funcional e inflamatória em pacientes asmáticos submetidos a intervenção educativa
• Beneficiário: Beatriz Mangueira Saraiva
• Modalidade de apoio: Auxílio à Pesquisa - Regular