| Texto completo | |
| Autor(es): |
Gomes, Isabela Bronchtein
[1]
;
Ayo, Christiane Maria
[1]
;
Lopes, Alessandro Garcia
[2]
;
Kumano, Laurie Sayuri
[1]
;
de Faria Junior, Geraldo Magela
[1]
;
de Almeida Jr, Gildasio Castello
;
Castiglioni, Lilian
[1, 2]
;
de Mattos, Luiz Carlos
[1]
;
Brandao, Cinara Cassia
[1]
Número total de Autores: 9
|
| Afiliação do(s) autor(es): | [1] Fac Med Sao Jose do Rio Preto FAMERP, Dept Mol Biol, Lab Immunogenet, Sao Jose Do Rio Preto, SP - Brazil
[2] Sao Paulo State Univ Julio de Mesquista Filho UNE, Dept Biol, Sao Jose Do Rio Preto, SP - Brazil
Número total de Afiliações: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | MOLECULAR BIOLOGY REPORTS; v. 48, n. 11 SEP 2021. |
| Citações Web of Science: | 0 |
| Resumo | |
Background Until a few years ago, keratoconus was defined as a noninflammatory degenerative disease. However, recent studies have shown that the altered balance between inflammatory cytokines, proteases, and protease inhibitors, as well as free radicals and oxidants, have a crucial role in the pathogenesis of this disease. The aim of this study is to investigate whether interleukin 17 A G197A (rs2275913) and interleukin 17 F T7488C (rs763780) polymorphisms are associated with keratoconus in patients from a population of the northwestern region of the State of Sao Paulo, Brazil. Methods and Results 35 patients and 61 controls were enrolled. Genotyping of interleukin 17 A G197A and interleukin 17 F T7488C polymorphisms was carried out using the polymerase chain reaction-restriction fragment length polymorphism technique. Statistical analyses were conducted using the chi-square test, and an odds ratio with a 95% confidence interval was also calculated to evaluate the association between polymorphisms and disease. Evaluating interleukin 17 F T7488C, we found that the TT genotype is associated as a risk factor for keratoconus (P = 0.04; OR = 3.01; CI 1.11-8.14). As for evaluating interleukin 17 A G197A, the allele and genotype frequencies between patients and controls were compared and no statistically significant differences were found. Conclusions Our data showed that the interleukin 17 F T7488C polymorphisms may exert an influence in keratoconus. (AU) | |
| Processo FAPESP: | 15/17226-7 - Biomarcadores em doenças oculares |
| Beneficiário: | Gildásio Castello de Almeida Júnior |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 18/09448-8 - Expressão de miRNAs na Toxoplasmose ocular |
| Beneficiário: | Geraldo Magela de Faria Junior |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 18/16622-4 - Associação do polimorfismo MICA-129 com o desenvolvimento do ceratocone em uma população do Noroeste do Estado de São Paulo |
| Beneficiário: | Laurie Sayuri Kumano |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |